The dynamic role of the left dlPFC in neurovisceral integration: Differential effects of theta burst stimulation on vagally mediated heart rate variability and cognitive-affective processing.

IF 2.9 2区心理学 Q2 NEUROSCIENCES

Psychophysiology Pub Date : 2024-09-01 Epub Date: 2024-06-12 DOI:10.1111/psyp.14606

Maximilian Schmaußer, Markus Raab, Sylvain Laborde

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引用次数: 0

Abstract

Adapting to the ever-changing demands of the environment requires a complex interplay between cognitive-affective, neuronal, and autonomic processes. Vagally mediated heart rate variability (vmHRV) is positively associated with both cognitive-affective functioning and prefrontal cortex (PFC) activity. Accordingly, the Neurovisceral Integration Model has posited a shared role of the PFC in the regulation of cognitive-affective processes and autonomic nervous system (ANS) activity. While there are numerous correlational findings in this regard, no study so far has investigated whether the manipulation of PFC activity induces changes in vmHRV and cognitive-affective processing in an inter-dependent manner. In a sample of 64 participants, we examined the effects of continuous (cTBS; n = 21) and intermittent theta-burst stimulation (iTBS; n = 20) compared to sham stimulation (n = 23) over the left dorsolateral PFC (dlPFC) on vmHRV and cognitive-affective processing within an emotional stop-signal task (ESST). Our results revealed that both resting vmHRV and vmHRV reactivity predicted cognitive-affective processing. Furthermore, we found a dampening effect of cTBS on resting and on-task vmHRV, as well as an enhancing effect of iTBS on ESST performance. Our results show no direct association between vmHRV changes and ESST performance alterations following stimulation. We interpret our results in the light of a hierarchical model of neurovisceral integration, suggesting a dynamical situation-dependent recruitment of higher-order cortical areas like the dlPFC in the regulation of the ANS. In conclusion, our results highlight the complex interplay between PFC activity, autonomic regulation, and cognitive-affective processing, emphasizing the need for further research to understand the causal dynamics of the underlying neural mechanisms.

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左侧大脑皮质在神经-内脏整合中的动态作用：θ脉冲刺激对迷走神经介导的心率变异性和认知情感处理的不同影响。

要适应不断变化的环境需求，需要认知-情感、神经元和自主神经过程之间复杂的相互作用。迷走神经介导的心率变异性（vmHRV）与认知-情感功能和前额叶皮质（PFC）活动呈正相关。因此，"神经-内脏整合模型"（Neurovisceral Integration Model）认为前额叶皮质在认知-情感过程和自律神经系统（ANS）活动的调节中发挥着共同的作用。虽然在这方面有许多相关研究结果，但迄今为止还没有研究表明，操纵前脑功能区的活动是否会以一种相互依存的方式引起 vmHRV 和认知情感处理的变化。我们以 64 名参与者为样本，研究了在情绪停止信号任务（ESST）中，连续（cTBS；n = 21）和间歇θ-猝发刺激（iTBS；n = 20）与假刺激（n = 23）对左侧背外侧 PFC（dlPFC）的 vmHRV 和认知情感处理的影响。我们的研究结果表明，静息vmHRV和vmHRV反应性都能预测认知情感处理。此外，我们还发现 cTBS 对静息和任务中的 vmHRV 有抑制作用，而 iTBS 则对 ESST 表现有增强作用。我们的研究结果表明，刺激后 vmHRV 的变化与 ESST 表现的改变之间没有直接联系。我们根据神经-内脏整合的层次模型来解释我们的结果，这表明在调节自律神经系统时，高阶皮质区域（如 dlPFC）会根据情况动态招募。总之，我们的研究结果凸显了大脑皮层功能区活动、自律神经调节和认知-情感处理之间复杂的相互作用，强调了进一步研究以了解潜在神经机制因果动态的必要性。

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来源期刊

Psychophysiology 医学-神经科学

CiteScore

6.80

自引率

8.10%

发文量

225

审稿时长

2 months

期刊介绍： Founded in 1964, Psychophysiology is the most established journal in the world specifically dedicated to the dissemination of psychophysiological science. The journal continues to play a key role in advancing human neuroscience in its many forms and methodologies (including central and peripheral measures), covering research on the interrelationships between the physiological and psychological aspects of brain and behavior. Typically, studies published in Psychophysiology include psychological independent variables and noninvasive physiological dependent variables (hemodynamic, optical, and electromagnetic brain imaging and/or peripheral measures such as respiratory sinus arrhythmia, electromyography, pupillography, and many others). The majority of studies published in the journal involve human participants, but work using animal models of such phenomena is occasionally published. Psychophysiology welcomes submissions on new theoretical, empirical, and methodological advances in: cognitive, affective, clinical and social neuroscience, psychopathology and psychiatry, health science and behavioral medicine, and biomedical engineering. The journal publishes theoretical papers, evaluative reviews of literature, empirical papers, and methodological papers, with submissions welcome from scientists in any fields mentioned above.