Preclinical comparison study of experimental peri-implantitis between alveolar ridge preservation and spontaneous healing sites in infected and noninfected tooth: a randomized blinded in vivo study

IF 4.2 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Young-Chang Ko, Dongseob Lee, Obin Kwon, Yang-Jo Seol, Ki-Tae Koo, Yong-Moo Lee, Jungwon Lee
{"title":"Preclinical comparison study of experimental peri-implantitis between alveolar ridge preservation and spontaneous healing sites in infected and noninfected tooth: a randomized blinded in vivo study","authors":"Young-Chang Ko,&nbsp;Dongseob Lee,&nbsp;Obin Kwon,&nbsp;Yang-Jo Seol,&nbsp;Ki-Tae Koo,&nbsp;Yong-Moo Lee,&nbsp;Jungwon Lee","doi":"10.1002/JPER.23-0617","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>This study compared the progression of experimental peri-implantitis between alveolar ridge preservation (ARP) and spontaneous healing (SH) sites in infected (IT) and noninfected tooth (NIT).</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Bilateral mandibular third or fourth premolars of six beagle dogs were randomly assigned to IT and NIT groups. Before extraction, chronic dehiscence defects were created at the mesial root of mid-buccal area in IT group. Four weeks later, the mesial roots of the third and fourth premolars were extracted in all groups.ARP procedure was randomly conducted on one side of the extraction sockets using collagenated bovine bone substitutes and resorbable collagen membrane, and contralateral side was allowded spontaneous healing. After 12 weeks of healing, bone-level implants (ϕ 3.6 × 8.0 mm) were placed at the extraction sockets. Three months of ligature induced peri-implantitis and three months of spontaneous progression were allowed, with radiographs taken at each phase. Biopsies were retrieved at the implant site for histomorphometric, immunohistochemical, and polarized light-microscopic analyses.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Radiography demonstrated that the changes in the marginal bone level during the spontaneous progression period showed no significant differences between ARP and SH sites. Only small and/or nonsignificant differences in the progression of peri-implantitis were observed between ARP and SH sites in histomorphometric, immunohistochemical, and polarized light microscopic analyses. Additionally, the IT and NIT groups exhibited similar outcomes for most parameters.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>ARP with xenogenic bone substitutes might provide similarly robust results as SH sites regarding the progression of experimental peri-implantitis, irrespective of the infected or noninfected nature of the site before tooth extraction.</p>\n </section>\n </div>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":null,"pages":null},"PeriodicalIF":4.2000,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/JPER.23-0617","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of periodontology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/JPER.23-0617","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0

Abstract

Background

This study compared the progression of experimental peri-implantitis between alveolar ridge preservation (ARP) and spontaneous healing (SH) sites in infected (IT) and noninfected tooth (NIT).

Methods

Bilateral mandibular third or fourth premolars of six beagle dogs were randomly assigned to IT and NIT groups. Before extraction, chronic dehiscence defects were created at the mesial root of mid-buccal area in IT group. Four weeks later, the mesial roots of the third and fourth premolars were extracted in all groups.ARP procedure was randomly conducted on one side of the extraction sockets using collagenated bovine bone substitutes and resorbable collagen membrane, and contralateral side was allowded spontaneous healing. After 12 weeks of healing, bone-level implants (ϕ 3.6 × 8.0 mm) were placed at the extraction sockets. Three months of ligature induced peri-implantitis and three months of spontaneous progression were allowed, with radiographs taken at each phase. Biopsies were retrieved at the implant site for histomorphometric, immunohistochemical, and polarized light-microscopic analyses.

Results

Radiography demonstrated that the changes in the marginal bone level during the spontaneous progression period showed no significant differences between ARP and SH sites. Only small and/or nonsignificant differences in the progression of peri-implantitis were observed between ARP and SH sites in histomorphometric, immunohistochemical, and polarized light microscopic analyses. Additionally, the IT and NIT groups exhibited similar outcomes for most parameters.

Conclusion

ARP with xenogenic bone substitutes might provide similarly robust results as SH sites regarding the progression of experimental peri-implantitis, irrespective of the infected or noninfected nature of the site before tooth extraction.

Abstract Image

在受感染和未受感染的牙槽嵴保留区和自发愈合区进行实验性种植体周围炎的临床前比较研究:一项随机盲法体内研究。
背景:本研究比较了感染牙(IT)和非感染牙(NIT)的牙槽嵴保留(ARP)和自发愈合(SH)部位的实验性种植体周围炎的进展情况:方法:将 6 只猎犬的双侧下颌第三或第四前臼齿随机分配到 IT 组和 NIT 组。拔牙前,在 IT 组颊面中部的中根创建慢性开裂缺损。四周后,所有组别均拔除第三和第四前臼齿的中侧根。使用胶原牛骨替代物和可吸收胶原膜,在一侧拔牙窝随机进行 ARP 手术,对侧允许自发愈合。12 周愈合后,在拔牙窝植入骨水平种植体(ϕ 3.6 × 8.0 毫米)。三个月的结扎诱导种植体周围炎和三个月的自发进展期,每个阶段都要拍摄X光片。在种植部位取活体组织进行组织形态学、免疫组织化学和偏振光显微镜分析:结果:X 光片显示,在自发进展期,ARP 和 SH 植入部位的边缘骨水平变化无明显差异。在组织形态计量学、免疫组化和偏振光显微镜分析中,ARP和SH部位的种植体周围炎的进展仅存在微小和/或不显著的差异。此外,IT 组和 NIT 组在大多数参数上表现出相似的结果:结论:在实验性种植体周围炎的进展方面,使用异种骨替代物的 ARP 可提供与 SH 位点类似的稳健结果,而与拔牙前该位点的感染或非感染性质无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Journal of periodontology
Journal of periodontology 医学-牙科与口腔外科
CiteScore
9.10
自引率
7.00%
发文量
290
审稿时长
3-8 weeks
期刊介绍: The Journal of Periodontology publishes articles relevant to the science and practice of periodontics and related areas.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信