Bithiophene and coumestan derivatives from Eclipta prostrata (L.) L. and their hepatoprotective activity.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-06-13 DOI:10.1080/10286020.2024.2364912

Le Thi Giang, SeonJu Park, Nguyen Thi Cuc, Bui Huu Tai, Phan Van Kiem, Nguyen Thi Minh Hang, Ninh Khac Ban, Pham Van Cuong, Nguyen Xuan Nhiem

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引用次数: 0

Abstract

One new bithiophene derivative, 5-(but-3-en-1-yn-1-yl)-5'-(methoxymethyl)-2,2'-bithiophene (1), along with twelve known compounds, senecioester (2), tiglinsaureester (3), 5-acetoxymethyl-2'-(but-3-en-1-yn-1-yl)-2,5'-bithiophene (4), 5-(4-isovaleroyloxybut-1-ynyl)-2,2'-bithiophene (5), 5-hydroxymethyl-(2,5':2',5'')-terthienyl tiglate (6), 5-hydroxymethyl-(2,5':2',5'')-terthienyl agelate (7), 5- hydroxymethyl-2,5':2',5''-terthiophene dimethylacrylate (8), 5-methoxymethyl-2,2':5',2''-terthiophene (9), α-terthiophene (10), 1,3,8,9-tetrahydroxycoumestan 3-sulfate (11), demethylwedelolactone (12), and wedelolactone (13) were isolated from the methanol extract of aerial parts of Eclipta prostrata (L.) L. All isolated compounds were evaluated for the protective ability on the HepG2 cells. At the concentration of 100 μM, compounds 11-13 showed the highest hepatoprotective effects, with HepG2 cell viability ranging from 38.68% to 48.54%. Bithiophenes showed higher hepatoprotective cell viability than terthiophenes.

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Eclipta prostrata (L.) L.中的噻吩和香豆素衍生物及其保肝活性。

噻吩酯 (3)、5-乙酰氧甲基-2'-(丁-3-烯-1-炔-1-基)-2,5'-联噻吩 (4)、5-(4-异戊酰氧基丁-1-炔基)-2,2'-联噻吩 (5)、5-羟甲基-(2,5'：2',5'')-噻吩惕各酸酯 (6)、5-羟甲基-(2,5'：(2',5'')-噻吩基琼脂酸酯 (7)、5-羟甲基-2,5':2',5''-噻吩二甲基丙烯酸酯 (8)、5-甲氧基甲基-2,2'：5',2''-terthiophene (9)、α-terthiophene (10)、1,3,8,9-tetrahydroxycoumestan 3-sulfate (11)、demethylwedelolactone (12)和wedelolactone (13)。评估了所有分离化合物对 HepG2 细胞的保护能力。在 100 μM 的浓度下，化合物 11-13 的保肝效果最好，HepG2 细胞存活率为 38.68% 至 48.54%。双噻吩类化合物的保肝细胞活力高于三噻吩类化合物。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.