Temporal trends on the prevalence of renal disease and outcomes among patients with diabetes mellitus hospitalized by heart failure: findings from INCAex.

IF 2.7 Q3 ENDOCRINOLOGY & METABOLISM

Expert Review of Endocrinology & Metabolism Pub Date : 2024-09-01 Epub Date: 2024-06-12 DOI:10.1080/17446651.2024.2365769

José Carlos Arévalo-Lorido, Juana Carretero-Gomez, Alessia Rubini, Francisco Javier Félix-Redondo, Nicolás Roberto Robles Pérez Monteoliva, Miriam Hernández González, Elena Vázquez Jarén, Bárbara Cancho-Castellanos, Reyes González Fernández, Daniel Fernández-Bergés

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Abstract

Background: To assess 20-year time trends in the prevalence of diabetes mellitus (DM) among inpatients with heart failure (HF) and the influence of coexisting DM and kidney disease (KD) on outcomes.

Research design and methods: A retrospective study of patients was admitted due to HF, during the period 2000/2019. The period of follow-up was divided into three intervals according to the European Medical Agency approval of newer hypoglycemic drugs. We analyzed in-hospital mortality and outcomes during the follow-up period.

Results: A total of 4959 patients were included. Over time, prevalence of DM was significantly raising among women with HF (50 to 53.2%) and descending among men (50% to 46.8%, p = 0.02). Total mortality and readmissions were higher in patients with DM during the and second periods. However, no significant differences were found in the third-one (HR 1.14, 95% CI 0.94-1.39, p = 0.181). A protector role of oral hypoglycemic medications was observed in this last period. According to the presence of KD, the patients with both DM and KD were who presented most of the events.

Conclusions: Over the time analyzed, the prevalence of DM raised among women and decreased among men. DM influenced the prognosis of HF except in the third period when more protective hypoglycemic drugs started to be used.

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因心力衰竭住院的糖尿病患者中肾病患病率和预后的时间趋势：INCAex 的研究结果。

背景：评估心力衰竭（HF）住院患者中糖尿病（DM）患病率的20年时间趋势，以及并存的DM和肾脏疾病（KD）对预后的影响：对2000年至2019年期间因心力衰竭入院的患者进行回顾性研究。根据欧洲医学机构对新型降糖药物的批准情况，将随访期分为三个时间段。我们对随访期间的院内死亡率和结果进行了分析：结果：共纳入 4959 名患者。随着时间的推移，女性高血压患者的糖尿病患病率明显上升（从50%上升至53.2%），而男性患者的糖尿病患病率则有所下降（从50%下降至46.8%，P = 0.02）。在第一和第二阶段，糖尿病患者的总死亡率和再住院率均较高。然而，在第三阶段没有发现明显差异（HR 1.14，95% CI 0.94-1.39，p = 0.181）。在最后一个阶段，口服降糖药起到了保护作用。根据是否患有 KD，同时患有糖尿病和 KD 的患者发生的事件最多：结论：在分析的时间段内，女性的糖尿病患病率上升，而男性的患病率下降。糖尿病对高血压的预后有影响，但第三阶段除外，因为此时开始使用更具保护性的降糖药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Endocrinology & Metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

4.80

自引率

0.00%

发文量

期刊介绍： Implicated in a plethora of regulatory dysfunctions involving growth and development, metabolism, electrolyte balances and reproduction, endocrine disruption is one of the highest priority research topics in the world. As a result, we are now in a position to better detect, characterize and overcome the damage mediated by adverse interaction with the endocrine system. Expert Review of Endocrinology and Metabolism (ISSN 1744-6651), provides extensive coverage of state-of-the-art research and clinical advancements in the field of endocrine control and metabolism, with a focus on screening, prevention, diagnostics, existing and novel therapeutics, as well as related molecular genetics, pathophysiology and epidemiology.