Role of Plant Materials with Anti-inflammatory Effects in Phytotherapy of Osteoarthritis.

IF 2.9 4区 医学 Q3 CHEMISTRY, MEDICINAL
Małgorzata Geszke-Moritz, Gerard Nowak, Michał Moritz, Barbara Feist, Jacek E Nycz
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引用次数: 0

Abstract

Osteoarthritis (OA) is a common chronic articular degenerative disease characterized by articular cartilage degradation, synovial inflammation/immunity, and subchondral bone lesions. Recently, increasing interest has been devoted to treating or preventing OA with herbal medicines. The mechanism of action of plant raw materials used in osteoarthrosis treatment is well documented. They are sought after because of the high frequency of inflammation of the knee joint among both elderly and young people engaged in sports in which their knee joints are often exposed to high-stress conditions. The purpose of this work was to present some most effective and safe plant medicines with proven mechanisms of action that can help to alleviate the growing social problem of osteoarthrosis caused in recent years. A review of the available literature based primarily on the latest editions of ESCOP and EMA monographs and the latest scientific papers has made it possible to select and propose medical management of osteoarthrosis by ranking plant medicines according to their effectiveness. Clinical studies of raw plant materials, such as Harpagophyti radix, Olibanum indicum, and Urticae foliumet herba have indicated that these drugs should be considered the first choice in osteoarthrosis treatment. The efficacy of Rosae pseudo-fructus, Salicis cortex, Filipendulae ulmariae flos et herba, Ribis nigri folium, and externally applied Capsici fructus and Symphyti radix, has also been proven by pharmacological studies. All the plant medicines mentioned in the paper have been studied in detail in terms of their phytochemistry, which can help doctors in their decision-- making in the treatment of osteoarthrosis.

具有抗炎作用的植物材料在骨关节炎植物疗法中的作用
骨关节炎(OA)是一种常见的慢性关节退行性疾病,以关节软骨退化、滑膜炎症/免疫和软骨下骨病变为特征。最近,人们越来越关注用中草药治疗或预防 OA。用于骨关节病治疗的植物原料的作用机理已得到充分证实。由于从事体育运动的老年人和年轻人膝关节经常处于高应力状态下,因此膝关节炎症的发病率很高,植物原料也因此受到追捧。这项工作的目的是介绍一些最有效、最安全的植物药,它们的作用机制已得到证实,有助于缓解近年来日益严重的骨关节病社会问题。主要根据最新版的 ESCOP 和 EMA 专论以及最新的科学论文,对现有文献进行了审查,从而根据植物药的有效性进行排序,选择并提出了骨关节病的医疗管理建议。对 Harpagophyti radix、Olibanum indicum 和 Urticae foliumet herba 等植物原料的临床研究表明,这些药物应被视为骨关节病治疗的首选。Rosae pseudo-fructus、Salicis cortex、Filipendulae ulmariae flos et herba、Ribis nigri folium 以及外敷的 Capsici fructus 和 Symphyti radix 的疗效也已通过药理学研究得到证实。本文提到的所有植物药都经过了详细的植物化学研究,可以帮助医生在治疗骨关节病时做出决策。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.40
自引率
2.90%
发文量
186
审稿时长
3-8 weeks
期刊介绍: Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.
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