Evaluation of beneficial effects of dexpanthenol on hypoxic-ischemic encephalopathy.

IF 1.6 4区生物学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biotechnic & Histochemistry Pub Date : 2024-06-13 DOI:10.1080/10520295.2024.2365231

Cuneyt Tayman, Ufuk Çakır, Abdullah Kurt, Ömer Ertekin, Tugba Taskin Turkmenoglu, Murat Çağlayan, Eray Işık

{"title":"Evaluation of beneficial effects of dexpanthenol on hypoxic-ischemic encephalopathy.","authors":"Cuneyt Tayman, Ufuk Çakır, Abdullah Kurt, Ömer Ertekin, Tugba Taskin Turkmenoglu, Murat Çağlayan, Eray Işık","doi":"10.1080/10520295.2024.2365231","DOIUrl":null,"url":null,"abstract":"Hypoxic-ischemic encephalopathy (HIE) is a cause of serious morbidity and mortality in newborns. Dexpanthenol, which is metabolized into D-pantothenic acid, has antioxidant and other potentially therapeutic properties. We examined some effects of dexpanthenol on the brains of week-old rat pups with HIE induced by obstruction of the right carotid artery followed by keeping in 8% O2 for 2 hours. Dexpanthenol (500 mg/kg) was administered intraperitoneally to 16 of 32 pups with HIE. Protein, DNA, and lipid oxidation degradation products were assayed and hippocampal and cortical cell apoptosis and neuronal cell numbers were evaluated in stained sections. Dexpanthenol application reduced oxidative stress and inflammation. TNF-α and IL-6 cytokine levels in HIE also decreased with dexpanthenol treatment. The numbers of caspase-3 positive cells in the dentate gyrus and CA1/CA2/CA3 regions of the hippocampus was lower, and apoptosis was decreased in the dexpanthenol-treated animals. These findings suggest possible clinical applications of dexpanthenol in human HIE.","PeriodicalId":8970,"journal":{"name":"Biotechnic & Histochemistry","volume":" ","pages":"1-9"},"PeriodicalIF":1.6000,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biotechnic & Histochemistry","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1080/10520295.2024.2365231","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Hypoxic-ischemic encephalopathy (HIE) is a cause of serious morbidity and mortality in newborns. Dexpanthenol, which is metabolized into D-pantothenic acid, has antioxidant and other potentially therapeutic properties. We examined some effects of dexpanthenol on the brains of week-old rat pups with HIE induced by obstruction of the right carotid artery followed by keeping in 8% O₂ for 2 hours. Dexpanthenol (500 mg/kg) was administered intraperitoneally to 16 of 32 pups with HIE. Protein, DNA, and lipid oxidation degradation products were assayed and hippocampal and cortical cell apoptosis and neuronal cell numbers were evaluated in stained sections. Dexpanthenol application reduced oxidative stress and inflammation. TNF-α and IL-6 cytokine levels in HIE also decreased with dexpanthenol treatment. The numbers of caspase-3 positive cells in the dentate gyrus and CA1/CA2/CA3 regions of the hippocampus was lower, and apoptosis was decreased in the dexpanthenol-treated animals. These findings suggest possible clinical applications of dexpanthenol in human HIE.

查看原文本刊更多论文

评估右泛醇对缺氧缺血性脑病的有益影响

缺氧缺血性脑病（HIE）是导致新生儿严重发病和死亡的原因之一。脱泛醇可代谢成 D-泛酸，具有抗氧化和其他潜在的治疗作用。我们研究了右颈动脉阻塞后在8%的氧气中保存2小时诱发HIE的一周大幼鼠大脑中去泛醇的一些作用。对 32 只 HIE 幼鼠中的 16 只进行腹腔注射右泛醇（500 毫克/千克）。对蛋白质、DNA和脂质氧化降解产物进行检测，并在染色切片中评估海马和皮质细胞凋亡情况和神经细胞数量。应用去泛醇可减少氧化应激和炎症反应。右泛醇治疗后，HIE 中的 TNF-α 和 IL-6 细胞因子水平也有所下降。右泛醇处理的动物海马齿状回和CA1/CA2/CA3区的caspase-3阳性细胞数量减少，细胞凋亡减少。这些研究结果表明，右泛酰苯酚可用于人类 HIE 的临床治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Biotechnic & Histochemistry 生物-生物工程与应用微生物

CiteScore

3.40

自引率

6.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Biotechnic & Histochemistry (formerly Stain technology) is the official publication of the Biological Stain Commission. The journal has been in continuous publication since 1926. Biotechnic & Histochemistry is an interdisciplinary journal that embraces all aspects of techniques for visualizing biological processes and entities in cells, tissues and organisms; papers that describe experimental work that employs such investigative methods are appropriate for publication as well. Papers concerning topics as diverse as applications of histochemistry, immunohistochemistry, in situ hybridization, cytochemical probes, autoradiography, light and electron microscopy, tissue culture, in vivo and in vitro studies, image analysis, cytogenetics, automation or computerization of investigative procedures and other investigative approaches are appropriate for publication regardless of their length. Letters to the Editor and review articles concerning topics of special and current interest also are welcome.