{"title":"Highly Efficient Two-Photon Photodynamic Therapy Using Light-Sheet Excitation","authors":"Wen Pang, Chen Wang, Wenbo Wu, Xunbin Wei, Bobo Gu","doi":"10.1002/lpor.202400753","DOIUrl":null,"url":null,"abstract":"Two-photon photodynamic therapy (TP-PDT), which utilizes near-infrared light to excite photosensitizer via two-photon excitation (TPE), is a promising modality in the treatment of deeply seated tumors or thick tumors. However, the TPE domain is much smaller than the tumor volume, significantly limiting the therapeutical outcomes of TP-PDT. Here, a light-sheet TPE system is designed and constructed using a cylindrical lens for highly efficient TP-PDT. The light-sheet TPE performance is characterized and optimized via theoretical analysis and experimental studies in solution, phantom, and tumor. The optimized excitation system can reach a large TPE domain of 2.6 × 2.7 × 0.09 mm in the tumor, which is not achievable using conventional TPE methods, enabling TPE and subsequently generated reactive oxygen species to cover the whole tumor under line-scanning. Outstanding TP-PDT therapeutic performance of 70% tumor growth inhibition rate is achieved under line-scanned light-sheet TPE, making the proposed light-sheet excited TP-PDT a potential therapeutic tool for future translational research.","PeriodicalId":204,"journal":{"name":"Laser & Photonics Reviews","volume":null,"pages":null},"PeriodicalIF":9.8000,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Laser & Photonics Reviews","FirstCategoryId":"101","ListUrlMain":"https://doi.org/10.1002/lpor.202400753","RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPTICS","Score":null,"Total":0}
引用次数: 0
Abstract
Two-photon photodynamic therapy (TP-PDT), which utilizes near-infrared light to excite photosensitizer via two-photon excitation (TPE), is a promising modality in the treatment of deeply seated tumors or thick tumors. However, the TPE domain is much smaller than the tumor volume, significantly limiting the therapeutical outcomes of TP-PDT. Here, a light-sheet TPE system is designed and constructed using a cylindrical lens for highly efficient TP-PDT. The light-sheet TPE performance is characterized and optimized via theoretical analysis and experimental studies in solution, phantom, and tumor. The optimized excitation system can reach a large TPE domain of 2.6 × 2.7 × 0.09 mm in the tumor, which is not achievable using conventional TPE methods, enabling TPE and subsequently generated reactive oxygen species to cover the whole tumor under line-scanning. Outstanding TP-PDT therapeutic performance of 70% tumor growth inhibition rate is achieved under line-scanned light-sheet TPE, making the proposed light-sheet excited TP-PDT a potential therapeutic tool for future translational research.
期刊介绍:
Laser & Photonics Reviews is a reputable journal that publishes high-quality Reviews, original Research Articles, and Perspectives in the field of photonics and optics. It covers both theoretical and experimental aspects, including recent groundbreaking research, specific advancements, and innovative applications.
As evidence of its impact and recognition, Laser & Photonics Reviews boasts a remarkable 2022 Impact Factor of 11.0, according to the Journal Citation Reports from Clarivate Analytics (2023). Moreover, it holds impressive rankings in the InCites Journal Citation Reports: in 2021, it was ranked 6th out of 101 in the field of Optics, 15th out of 161 in Applied Physics, and 12th out of 69 in Condensed Matter Physics.
The journal uses the ISSN numbers 1863-8880 for print and 1863-8899 for online publications.