Efficient selenium use by PRDX6 suppresses iron toxicity and ferroptosis

IF 12.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Structural & Molecular Biology Pub Date : 2024-06-12 DOI:10.1038/s41594-024-01330-6

引用次数: 0

Abstract

An iron-induced ferroptosis screen revealed PRDX6 as a selenoprotein-synthesis factor. Loss of PRDX6 substantially decreased expression of the selenoprotein GPX4, a master regulator of ferroptosis, and induced ferroptosis. Mechanistically, PRDX6 increases the efficiency of selenium use by acting as a selenium delivery protein.

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PRDX6 对硒的高效利用可抑制铁毒性和铁变态反应

铁诱导铁变态筛选发现，PRDX6是一种硒蛋白合成因子。缺失 PRDX6 会大大降低硒蛋白 GPX4（铁变态反应的主要调节因子）的表达，并诱导铁变态反应。从机理上讲，PRDX6 通过充当硒输送蛋白提高了硒的利用效率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.