Photo induced eosin-Y catalyzed synthesis and molecular docking studies of 5,5-diphenylimidazolidine-2,4-dione

IF 1.8 3区化学 Q3 CHEMISTRY, ORGANIC

Synthetic Communications Pub Date : 2024-05-29 DOI:10.1080/00397911.2024.2358370

Km Garima , Rohit Kumar , Vishal Srivastava , Praveen Pratap Singh , Pravin Kumar Singh

引用次数: 0

Abstract

One-pot photo induced eosin-Y catalyzed, green approach for the synthesis of 5,5-diphenylimidazolidine-2,4-dione (Phenytoin) has been developed. The reaction proceeded smoothly, for a wide range of benzil and urea/thiourea derivatives as cheap and eco friendly reagents with high reactivity and good selectivity in DMSO as green solvent at room temperature in good to excellent yields. Biological studies such as drug-likeness and molecular docking have been conducted on the synthesized compounds, some of the compounds showed appreciable activity with least binding energy.

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光诱导曙红-Y 催化合成 5,5-二苯基咪唑烷-2,4-二酮及其分子对接研究

本研究开发了一种单锅光诱导伊红催化合成 5,5-二苯基咪唑烷-2,4-二酮（苯妥英）的绿色方法。在室温下，以二甲基亚砜（DMSO）为绿色溶剂，以廉价、环保、高反应活性和良好选择性的多种苯齐和脲/硫脲衍生物为试剂，反应进行顺利，产率良好甚至极佳。对合成的化合物进行了药物相似性和分子对接等生物学研究，其中一些化合物以最低的结合能表现出了明显的活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Synthetic Communications 化学-有机化学

CiteScore

4.40

自引率

4.80%

发文量

156

审稿时长

4.3 months

期刊介绍： Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.