Presynaptic regulators in memory formation.

IF 1.8 4区医学 Q4 NEUROSCIENCES

Learning & memory Pub Date : 2024-06-11 Print Date: 2024-05-01 DOI:10.1101/lm.054013.124

Oriane Turrel, Lili Gao, Stephan J Sigrist

引用次数: 0

Abstract

The intricate molecular and structural sequences guiding the formation and consolidation of memories within neuronal circuits remain largely elusive. In this study, we investigate the roles of two pivotal presynaptic regulators, the small GTPase Rab3, enriched at synaptic vesicles, and the cell adhesion protein Neurexin-1, in the formation of distinct memory phases within the Drosophila mushroom body Kenyon cells. Our findings suggest that both proteins play crucial roles in memory-supporting processes within the presynaptic terminal, operating within distinct plasticity modules. These modules likely encompass remodeling and maturation of existing active zones (AZs), as well as the formation of new AZs.

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记忆形成过程中的突触前调节器

在神经元回路中，指导记忆形成和巩固的错综复杂的分子和结构序列在很大程度上仍然是难以捉摸的。在这项研究中，我们研究了两种关键的突触前调节因子在果蝇蘑菇体肯尼恩细胞内不同记忆阶段形成过程中的作用，这两种因子是富含于突触小泡的小 GTP 酶 Rab3 和细胞粘附蛋白 Neurexin-1。我们的研究结果表明，这两种蛋白在突触前末端的记忆支持过程中发挥着关键作用，在不同的可塑性模块中运作。这些模块可能包括现有活性区（AZ）的重塑和成熟，以及新活性区的形成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Learning & memory 医学-神经科学

CiteScore

3.60

自引率

5.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The neurobiology of learning and memory is entering a new interdisciplinary era. Advances in neuropsychology have identified regions of brain tissue that are critical for certain types of function. Electrophysiological techniques have revealed behavioral correlates of neuronal activity. Studies of synaptic plasticity suggest that some mechanisms of memory formation may resemble those of neural development. And molecular approaches have identified genes with patterns of expression that influence behavior. It is clear that future progress depends on interdisciplinary investigations. The current literature of learning and memory is large but fragmented. Until now, there has been no single journal devoted to this area of study and no dominant journal that demands attention by serious workers in the area, regardless of specialty. Learning & Memory provides a forum for these investigations in the form of research papers and review articles.