Feasibility study of focused ultrasound in the treatment of vulvar low-grade squamous intraepithelial lesions with persistent symptoms.

IF 3 3区 医学 Q2 ONCOLOGY
International Journal of Hyperthermia Pub Date : 2024-01-01 Epub Date: 2024-06-11 DOI:10.1080/02656736.2024.2365975
Chang Su, Xinglin Liu, Can Wu, Xi Wang, Chengzhi Li
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Abstract

Objective: This study aimed to investigate the feasibility, efficacy, and safety of focused ultrasound (FUS) for the treatment of vulvar low-grade squamous intraepithelial lesions (VLSIL) with persistent symptoms.

Methods: This retrospective analysis included 24 VLSIL patients who underwent FUS treatment. At each follow-up visit, the clinical response was assessed including changes in symptoms and signs. In addition, the histological response was assessed based on the vulvar biopsy results of the 3rd follow-up. Clinical and histological response were assessed to elucidate the efficacy.

Results: A total of 22 patients completed follow-up and post-treatment pathological biopsies. After treatment, the clinical scores of itching decreased from 2.55 ± 0.51 to 0.77 ± 0.81 (p < 0.05). Furthermore, the clinical response rate and histological response rate were 86.4% and 81.8%, respectively. Only two cured patients indicated recurrence in the 3rd and 4th year during the follow-up period and achieved cure after re-treatment. In terms of adverse effects, only one patient developed ulcers after treatment, which healed after symptomatic anti-inflammatory treatment without scarring, and no other treatment complications were found in any patients. None of the patients developed a malignant transformation during the follow-up period.

Conclusion: This study revealed that FUS is feasible, effective, and safe for treating VLSIL patients with persistent symptoms, providing a new solution for the noninvasive treatment of symptomatic VLSIL.

聚焦超声治疗伴有持续症状的外阴低级别鳞状上皮内病变的可行性研究。
研究目的本研究旨在探讨聚焦超声(FUS)治疗伴有持续症状的外阴低级别鳞状上皮内病变(VLSIL)的可行性、有效性和安全性:这项回顾性分析包括24名接受FUS治疗的VLSIL患者。在每次随访时,对临床反应进行评估,包括症状和体征的变化。此外,根据第三次随访的外阴活检结果评估组织学反应。对临床和组织学反应的评估旨在阐明疗效:共有22名患者完成了随访和治疗后病理活检。治疗后,瘙痒的临床评分从(2.55±0.51)分降至(0.77±0.81)分(p 结论:FUS 是一种有效的治疗方法,可用于治疗溃疡:该研究表明,FUS 治疗有顽固症状的 VLSIL 患者是可行、有效和安全的,为无创治疗有症状的 VLSIL 提供了新的解决方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.90
自引率
12.90%
发文量
153
审稿时长
6-12 weeks
期刊介绍: The International Journal of Hyperthermia
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