A bidirectional Mendelian randomization analysis between COVID-19 and cardiac arrest.

IF 2.2 4区医学 Q3 ENVIRONMENTAL SCIENCES

International Journal of Environmental Health Research Pub Date : 2025-01-01 Epub Date: 2024-06-12 DOI:10.1080/09603123.2024.2365304

Xisha Tang, Huijia Zhuang, Hai Yu

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引用次数: 0

Abstract

Epidemiological studies link COVID-19 to increased cardiac arrest (CA) risk, but causality remains unclear due to potential confounding factors in observational studies . We conducted a Mendelian randomization (MR) analysis using genome-wide association study (GWAS) data, employing COVID-19-associated single nucleotide polymorphisms (SNPs) with significance values smaller than 5 × 10⁻⁸. We calculated inverse-variance weighted (IVW) MR estimates and performed sensitivity analyses using MR methods robust to horizontal pleiotropy. Additionally, a reverse MR analysis was conducted using CA-associated SNPs with significance values smaller than 1 × 10⁻⁵. Results indicated that infected COVID-19 (OR = 1.12, 95% CI = 0.47-2.67, p = 0.79), hospitalized COVID-19 (OR = 1.02, 95% CI = 0.70-1.49, p = 0.920), and severe respiratory COVID-19 (OR = 0.99, 95% CI = 0.81-1.21, p = 0.945) did not causally influence CA risk. Reverse MR analysis also did not support a causal effect of CA on COVID-19. Thus, associations in observational studies may stem from shared biological factors or environmental confounding.

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COVID-19 与心脏骤停之间的双向孟德尔随机分析。

流行病学研究表明 COVID-19 与心脏骤停（CA）风险增加有关，但由于观察性研究中潜在的混杂因素，因果关系仍不明确。我们利用全基因组关联研究（GWAS）数据，采用显著性值小于 5 × 10-⁸ 的 COVID-19 相关单核苷酸多态性（SNPs），进行了孟德尔随机化（MR）分析。我们计算了反方差加权（IVW）MR 估计值，并使用对水平多向性具有稳健性的 MR 方法进行了敏感性分析。此外，我们还使用显著性值小于 1 × 10-⁵ 的 CA 相关 SNP 进行了反向 MR 分析。结果表明，感染 COVID-19（OR = 1.12，95% CI = 0.47-2.67，p = 0.79）、住院 COVID-19（OR = 1.02，95% CI = 0.70-1.49，p = 0.920）和严重呼吸道 COVID-19（OR = 0.99，95% CI = 0.81-1.21，p = 0.945）不会对 CA 风险产生因果影响。反向 MR 分析也不支持 CA 对 COVID-19 的因果效应。因此，观察性研究中的关联可能源于共同的生物因素或环境混杂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Environmental Health Research 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.70

自引率

3.10%

发文量

134

审稿时长

>12 weeks

期刊介绍： International Journal of Environmental Health Research ( IJEHR ) is devoted to the rapid publication of research in environmental health, acting as a link between the diverse research communities and practitioners in environmental health. Published articles encompass original research papers, technical notes and review articles. IJEHR publishes articles on all aspects of the interaction between the environment and human health. This interaction can broadly be divided into three areas: the natural environment and health – health implications and monitoring of air, water and soil pollutants and pollution and health improvements and air, water and soil quality standards; the built environment and health – occupational health and safety, exposure limits, monitoring and control of pollutants in the workplace, and standards of health; and communicable diseases – disease spread, control and prevention, food hygiene and control, and health aspects of rodents and insects. IJEHR is published in association with the International Federation of Environmental Health and includes news from the Federation of international meetings, courses and environmental health issues.