Biosurfactant complexed with arginine has antibiofilm activity against methicillin-resistant Staphylococcus aureus.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-01-01 Epub Date: 2024-06-12 DOI:10.2217/fmb-2023-0271

Fatima Daiana Dias Barroso, Lisandra Juvêncio da Silva, Helaine Almeida Queiroz, Lívia Gurgel do Amaral Valente Sá, Anderson Ramos da Silva, Cecília Rocha da Silva, João Batista de Andrade Neto, Bruno Coêlho Cavalcanti, Manoel Odorico de Moraes, Aurora Pinazo, Lourdes Pérez, Hélio Vitoriano Nobre Júnior

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引用次数: 0

Abstract

Aim: The present study investigated the antimicrobial effectiveness of a rhamnolipid complexed with arginine (RLMIX_Arg) against planktonic cells and biofilms of methicillin-resistant Staphylococcus aureus (MRSA). Methodology: Susceptibility testing was performed using the Clinical & Laboratory Standards Institute protocol: M07-A10, checkerboard test, biofilm in plates and catheters and flow cytometry were used. Result: RLMIX_Arg has bactericidal and synergistic activity with oxacillin. RLMIX_Arg inhibits the formation of MRSA biofilms on plates at sub-inhibitory concentrations and has antibiofilm action against MRSA in peripheral venous catheters. Catheters impregnated with RLMIX_Arg reduce the formation of MRSA biofilms. Conclusion: RLMIX_Arg exhibits potential for application in preventing infections related to methicillin-resistant S. aureus biofilms.

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与精氨酸复配的生物表面活性剂对耐甲氧西林金黄色葡萄球菌具有抗生物膜活性。

目的：本研究调查了鼠李糖脂与精氨酸复合物（RLMIX_Arg）对耐甲氧西林金黄色葡萄球菌（MRSA）浮游细胞和生物膜的抗菌效果。方法：药敏试验采用临床与实验室标准研究所（Clinical & Laboratory Standards Institute）的方案进行：使用了 M07-A10、棋盘试验、平板和导管中的生物膜以及流式细胞仪。结果：RLMIX_Arg 与奥沙西林具有杀菌和协同活性。在亚抑制浓度下，RLMIX_Arg 可抑制平板上 MRSA 生物膜的形成，并对外周静脉导管中的 MRSA 具有抗生物膜作用。浸渍了 RLMIX_Arg 的导管可减少 MRSA 生物膜的形成。结论：RLMIX_Arg 具有应用于预防耐甲氧西林金黄色葡萄球菌生物膜感染的潜力。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464