Empagliflozin in the treatment of heart failure.

IF 1.6 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Future cardiology Pub Date : 2024-04-25 Epub Date: 2024-06-12 DOI:10.1080/14796678.2024.2360818
Aimen Shafiq, Ishaque Hameed, Jan Biegus, Marat Fudim, Muhammad Shahzeb Khan
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引用次数: 0

Abstract

Heart failure (HF) affects more than 60 million individuals globally. Empagliflozin is currently approved for type 2 diabetes and chronic HF. Clinical trials have demonstrated that empagliflozin reduces the composite end point of hospitalizations for HF and mortality and improves the quality of life irrespective of left ventricular ejection fraction. Empagliflozin is a once-daily medication with minimal drug-drug interactions and does not require titration. Empagliflozin causes mild weight loss and does not significantly reduce blood pressure. Empagliflozin acts as an enabler for other HF drugs by reducing the risk of hyperkalemia. Empagliflozin is also beneficial for chronic kidney disease which exists commonly with HF. This review outlines the pharmacokinetics, pharmacodynamics, safety, and efficacy of empagliflozin in HF across various sub-groups and settings.

Empagliflozin 用于治疗心力衰竭。
心力衰竭(HF)影响着全球 6000 多万人。目前,恩格列净已获准用于治疗 2 型糖尿病和慢性心力衰竭。临床试验表明,无论左心室射血分数如何,Empagliflozin 都能降低心力衰竭住院率和死亡率的综合终点,并改善生活质量。Empagliflozin 每日用药一次,药物间相互作用极小,无需滴定。Empagliflozin 会导致轻度体重减轻,并且不会明显降低血压。Empagliflozin 可降低高钾血症的风险,从而成为其他高血压药物的辅助药物。Empagliflozin 还有益于慢性肾病,而慢性肾病通常与高血压同时存在。本综述概述了 Empagliflozin 在不同亚组和不同情况下治疗高血压的药代动力学、药效学、安全性和有效性。
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来源期刊
Future cardiology
Future cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
2.80
自引率
5.90%
发文量
87
期刊介绍: Research advances have contributed to improved outcomes across all specialties, but the rate of advancement in cardiology has been exceptional. Concurrently, the population of patients with cardiac conditions continues to grow and greater public awareness has increased patients" expectations of new drugs and devices. Future Cardiology (ISSN 1479-6678) reflects this new era of cardiology and highlights the new molecular approach to advancing cardiovascular therapy. Coverage will also reflect the major technological advances in bioengineering in cardiology in terms of advanced and robust devices, miniaturization, imaging, system modeling and information management issues.
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