The role of high-temperature requirement A1 in breast cancer

IF 1 Q4 GENETICS & HEREDITY

Gene Reports Pub Date : 2024-06-06 DOI:10.1016/j.genrep.2024.101946

Dawei Zhao , Hong Yu

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引用次数: 0

Abstract

Breast cancer is the most common cancer in women worldwide. The high-temperature requirement A (HTRA) protein family is a highly conserved serine protease family that plays a critical role in the regulation of several important physiological processes such as cell growth, apoptosis, and senescence. It has also been implicated in the pathogenesis, diagnosis, progression, and prognosis of several types of cancer. HTRA1 is the first and most extensively studied member of the HTRA family, which plays a pivotal role in the pathogenesis and progression of various cancers. In breast cancer, HTRA1 is involved in the regulation of tumor cell, proliferation, migration, and invasion. Clinically, it may also be involved in chemotherapy resistance. A thorough investigation of the mechanism of HTRA1 in breast cancer progression is crucial for the implementation of disease diagnosis and individualized medicine. This review provides a comprehensive overview of the current progress of HTRA1 in breast cancer research, focusing on its molecular characteristics, tissue distribution, potential substrates, involved signaling pathways, and interactions with upstream and downstream molecules.

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高温要求 A1 在乳腺癌中的作用

乳腺癌是全球妇女最常见的癌症。高温要求 A（HTRA）蛋白家族是一个高度保守的丝氨酸蛋白酶家族，在调节细胞生长、凋亡和衰老等几个重要生理过程中发挥着关键作用。它还与几种癌症的发病机制、诊断、进展和预后有关。HTRA1 是 HTRA 家族中第一个也是研究最广泛的成员，它在各种癌症的发病和进展过程中起着关键作用。在乳腺癌中，HTRA1 参与调控肿瘤细胞的增殖、迁移和侵袭。在临床上，它还可能与化疗耐药性有关。深入研究 HTRA1 在乳腺癌进展过程中的作用机制对于疾病诊断和个体化医疗的实施至关重要。本综述全面概述了 HTRA1 在乳腺癌研究中的最新进展，重点关注其分子特征、组织分布、潜在底物、参与的信号通路以及与上下游分子的相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gene Reports Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.30

自引率

7.70%

发文量

246

审稿时长

49 days

期刊介绍： Gene Reports publishes papers that focus on the regulation, expression, function and evolution of genes in all biological contexts, including all prokaryotic and eukaryotic organisms, as well as viruses. Gene Reports strives to be a very diverse journal and topics in all fields will be considered for publication. Although not limited to the following, some general topics include: DNA Organization, Replication & Evolution -Focus on genomic DNA (chromosomal organization, comparative genomics, DNA replication, DNA repair, mobile DNA, mitochondrial DNA, chloroplast DNA). Expression & Function - Focus on functional RNAs (microRNAs, tRNAs, rRNAs, mRNA splicing, alternative polyadenylation) Regulation - Focus on processes that mediate gene-read out (epigenetics, chromatin, histone code, transcription, translation, protein degradation). Cell Signaling - Focus on mechanisms that control information flow into the nucleus to control gene expression (kinase and phosphatase pathways controlled by extra-cellular ligands, Wnt, Notch, TGFbeta/BMPs, FGFs, IGFs etc.) Profiling of gene expression and genetic variation - Focus on high throughput approaches (e.g., DeepSeq, ChIP-Seq, Affymetrix microarrays, proteomics) that define gene regulatory circuitry, molecular pathways and protein/protein networks. Genetics - Focus on development in model organisms (e.g., mouse, frog, fruit fly, worm), human genetic variation, population genetics, as well as agricultural and veterinary genetics. Molecular Pathology & Regenerative Medicine - Focus on the deregulation of molecular processes in human diseases and mechanisms supporting regeneration of tissues through pluripotent or multipotent stem cells.