Neurotoxic and cardiotoxic effects of pyrogallol on catfish (Clarias gariepinus)

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2024-06-08 DOI:10.1016/j.etap.2024.104481

Mohamed Hamed , Christopher J. Martyniuk , Hamdy A.M. Soliman , Alaa G.M. Osman , Rashad E.M. Said

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Abstract

Pyrogallol, a botanical hydrolysable tannin, has diverse medical and industrial applications. Its impact on aquatic ecosystems and fish health has been previously studied, revealing histopathological, immunological, biochemical, and haematological alterations in African catfish (Clarias gariepinus). In this study, the neurotoxic potential of pyrogallol was assessed through a 15-day exposure of catfish to concentrations of 1, 5, or 10 mg/L. Enzyme activities such as acetylcholinesterase (AchE), monoamine oxidase (MAO), aldehyde oxidase (AO), and nitric oxide (NO) were measured in serum and brain, along with histopathological examinations in the brain and heart. Pyrogallol exposure led to decreased AchE activity in the brain and serum, increased serum MAO activity, elevated AO in both brain and serum, and suppressed NO levels. Morphological abnormalities and dose-dependent pathological alterations were observed in the brain and heart, including neuropile deformities, shrunken Purkinje cells, cardiomyocyte degeneration, and increased collagen fibers. This suggests that pyrogallol induces adverse effects in fish.

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焦谷醇对鲶鱼的神经毒性和心脏毒性作用

焦酚是一种植物水解单宁，具有多种医疗和工业用途。以前曾研究过它对水生生态系统和鱼类健康的影响，发现它对非洲鲶鱼（Clarias gariepinus）造成了组织病理学、免疫学、生物化学和血液学方面的改变。在本研究中，通过让鲶鱼暴露于 1、5 或 10 毫克/升的浓度下 15 天，对焦棓酚的神经毒性潜力进行了评估。测量了血清和大脑中乙酰胆碱酯酶（AchE）、单胺氧化酶（MAO）、醛氧化酶（AO）和一氧化氮（NO）等酶的活性，并对大脑和心脏进行了组织病理学检查。接触焦谷醇会导致大脑和血清中 AchE 活性降低、血清 MAO 活性升高、大脑和血清中 AO 升高以及 NO 水平降低。在大脑和心脏中观察到了形态异常和剂量依赖性病理变化，包括神经瘫痪、浦肯野细胞萎缩、心肌细胞变性和胶原纤维增加。这表明焦谷醇会对鱼类产生不良影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.