Hematological changes due to malaria – An update

IF 1.4 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular and biochemical parasitology Pub Date : 2024-06-08 DOI:10.1016/j.molbiopara.2024.111635

Rana Hussein Naser , Toktam Rajaii , Bibi Razieh Hosseini Farash , Seyyed javad Seyyedtabaei , Vahid Hajali , Fatemeh Sadabadi , Ehsan Saburi

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Abstract

Malaria, a parasitic infection caused by the genus Plasmodium, results to over 20 million reported cases annually worldwide. Most individuals exhibit various symptoms, and blood analysis plays a crucial role in determining the appropriate treatment approach. This study discusses various hematologic complications associated with different Plasmodium species. A review of scientific databases including PubMed, Science Direct, Web of Science, Scopus, EMBASE, Magiran, SID, IranMedex was conducted using standard keywords such as Plasmodium, malaria, anemia and blood disorders (hematologic disorder) between 2000 and 2024. The review focused on articles pertaining to clinical trials, prospective cohort, retrospective, cross-sectional and case-control studies. Articles evaluating the effects of malaria on blood cells and indices, with target groups including human and animals, were included. Articles not written in English or Farsi were excluded. Our review revealed that, apart from iron deficiency anemia and vascular dysfunction contributed in part by adhesion of infected RBC to endothelium, decreases in hematocrit and hemoglobin levels, as part of pancytopenia and thrombocytopenia, are characteristic of Plasmodium infection. Additionally, the occurrence of inflammation due to the release of inflammatory cytokines and complement activation can complicate the clinical features of malaria in individuals with hematologic conditions.

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疟疾引起的血液学变化--最新进展。

疟疾是一种由疟原虫引起的寄生虫感染，全世界每年报告的病例超过 2000 万。大多数人表现出各种症状，而血液分析在确定适当的治疗方法方面起着至关重要的作用。本研究讨论了与不同疟原虫种类相关的各种血液学并发症。本研究使用疟原虫、疟疾、贫血和血液疾病（血液病）等标准关键词对 2000-2024 年间的科学数据库（包括 PubMed、Science Direct、Web of Science、Scopus、EMBASE、Magiran、SID 和 IranMedex）进行了回顾。综述的重点是与临床试验、前瞻性队列研究、回顾性研究、横断面研究和病例对照研究有关的文章。其中包括评估疟疾对血细胞和指数影响的文章，研究对象包括人类和动物。非英语或波斯语的文章被排除在外。我们的综述显示，除了缺铁性贫血和血管功能障碍（部分原因是受感染的红细胞粘附在血管内皮上）外，血细胞比容和血红蛋白水平的下降以及全血细胞减少和血小板减少是疟原虫感染的特征。此外，炎症细胞因子的释放和补体激活导致的炎症也会使血液系统疾病患者的疟疾临床特征复杂化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular and biochemical parasitology 医学-寄生虫学

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

63 days

期刊介绍： The journal provides a medium for rapid publication of investigations of the molecular biology and biochemistry of parasitic protozoa and helminths and their interactions with both the definitive and intermediate host. The main subject areas covered are: • the structure, biosynthesis, degradation, properties and function of DNA, RNA, proteins, lipids, carbohydrates and small molecular-weight substances • intermediary metabolism and bioenergetics • drug target characterization and the mode of action of antiparasitic drugs • molecular and biochemical aspects of membrane structure and function • host-parasite relationships that focus on the parasite, particularly as related to specific parasite molecules. • analysis of genes and genome structure, function and expression • analysis of variation in parasite populations relevant to genetic exchange, pathogenesis, drug and vaccine target characterization, and drug resistance. • parasite protein trafficking, organelle biogenesis, and cellular structure especially with reference to the roles of specific molecules • parasite programmed cell death, development, and cell division at the molecular level.