Modulating the Expression of Exercise-induced lncRNAs: Implications for Cardiovascular Disease Progression.

IF 2.4 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiovascular Translational Research Pub Date : 2024-06-10 DOI:10.1007/s12265-024-10530-w

Li-Hua Yu, Ge-Lin Zhang

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Abstract

Recent research shows exercise is good for heart health, emphasizing the importance of physical activity. Sedentary behavior increases the risk of cardiovascular disease, while exercise can help prevent and treat it. Additionally, physical exercise can modulate the expression of lncRNAs, influencing cardiovascular disease progression. Therefore, understanding this relationship could help identify prospective biomarkers and therapeutic targets pertaining to cardiovascular ailments. This review has underscored recent advancements concerning the potential biomarkers of lncRNAs in cardiovascular diseases, while also summarizing existing knowledge regarding dysregulated lncRNAs and their plausible molecular mechanisms. Additionally, we have contributed novel perspectives on the underlying mechanisms of lncRNAs, which hold promise as potential biomarkers and therapeutic targets for cardiovascular conditions. The knowledge imparted in this review may prove valuable in guiding the design of future investigations and furthering the understanding of lncRNAs as diagnostic, prognostic, and therapeutic biomarkers for cardiovascular diseases.

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调节运动诱导的 lncRNAs 的表达：对心血管疾病进展的影响

最新研究表明，运动有益于心脏健康，强调了体育锻炼的重要性。久坐不动会增加罹患心血管疾病的风险，而运动则有助于预防和治疗心血管疾病。此外，体育锻炼还能调节 lncRNA 的表达，影响心血管疾病的进展。因此，了解这种关系有助于确定与心血管疾病相关的前瞻性生物标志物和治疗靶点。这篇综述强调了有关心血管疾病中lncRNAs潜在生物标志物的最新进展，同时还总结了有关失调lncRNAs及其合理分子机制的现有知识。此外，我们还对 lncRNAs 的潜在机制提出了新的观点，这些新观点有望成为心血管疾病的潜在生物标志物和治疗靶点。本综述中传授的知识可能对指导未来研究的设计和进一步了解作为心血管疾病诊断、预后和治疗生物标志物的 lncRNAs 很有价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cardiovascular Translational Research CARDIAC & CARDIOVASCULAR SYSTEMS-MEDICINE, RESEARCH & EXPERIMENTAL

CiteScore

6.10

自引率

2.90%

发文量

148

审稿时长

6-12 weeks

期刊介绍： Journal of Cardiovascular Translational Research (JCTR) is a premier journal in cardiovascular translational research. JCTR is the journal of choice for authors seeking the broadest audience for emerging technologies, therapies and diagnostics, pre-clinical research, and first-in-man clinical trials. JCTR''s intent is to provide a forum for critical evaluation of the novel cardiovascular science, to showcase important and clinically relevant aspects of the new research, as well as to discuss the impediments that may need to be overcome during the translation to patient care.