Micromanaging the neuroendocrine system – A review on miR-7 and the other physiologically relevant miRNAs in the hypothalamic–pituitary axis

IF 3.5 4区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Julian Zacharjasz, Marta Sztachera, Michał Smuszkiewicz, Monika Piwecka
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Abstract

The hypothalamic–pituitary axis is central to the functioning of the neuroendocrine system and essential for regulating physiological and behavioral homeostasis and coordinating fundamental body functions. The expanding line of evidence shows the indispensable role of the microRNA pathway in regulating the gene expression profile in the developing and adult hypothalamus and pituitary gland. Experiments provoking a depletion of miRNA maturation in the context of the hypothalamic–pituitary axis brought into focus a prominent involvement of miRNAs in neuroendocrine functions. There are also a few individual miRNAs and miRNA families that have been studied in depth revealing their crucial role in mediating the regulation of fundamental processes such as temporal precision of puberty timing, hormone production, fertility and reproduction capacity, and energy balance. Among these miRNAs, miR-7 was shown to be hypothalamus-enriched and the top one highly expressed in the pituitary gland, where it has a profound impact on gene expression regulation. Here, we review miRNA profiles, knockout phenotypes, and miRNA interaction (targets) in the hypothalamic–pituitary axis that advance our understanding of the roles of miRNAs in mammalian neurosecretion and related physiology.

Abstract Image

微观管理神经内分泌系统--综述下丘脑-垂体轴中的 miR-7 及其他生理相关 miRNA。
下丘脑-垂体轴是神经内分泌系统功能的核心,对于调节生理和行为平衡以及协调身体基本功能至关重要。越来越多的证据表明,microRNA 通路在调节发育中和成年的下丘脑和垂体的基因表达谱中发挥着不可或缺的作用。在下丘脑-垂体轴的背景下进行的miRNA成熟耗竭实验,使人们注意到miRNA在神经内分泌功能中的重要作用。此外,还对一些单个的 miRNA 和 miRNA 家族进行了深入研究,揭示了它们在调控青春期时间精确性、激素分泌、生育能力和生殖能力以及能量平衡等基本过程中的关键作用。在这些 miRNA 中,miR-7 被证明富集于下丘脑,是在垂体中高表达的头号 miRNA,对基因表达调控有深远影响。在这里,我们回顾了下丘脑-垂体轴中的 miRNA 图谱、基因敲除表型和 miRNA 相互作用(靶标),这些都有助于我们了解 miRNA 在哺乳动物神经分泌和相关生理学中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
FEBS Letters
FEBS Letters 生物-生化与分子生物学
CiteScore
7.00
自引率
2.90%
发文量
303
审稿时长
1.0 months
期刊介绍: FEBS Letters is one of the world''s leading journals in molecular biology and is renowned both for its quality of content and speed of production. Bringing together the most important developments in the molecular biosciences, FEBS Letters provides an international forum for Minireviews, Research Letters and Hypotheses that merit urgent publication.
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