Validation of a sampling method and liquid chromatography mass spectrometry analysis method for measurement of fentanyl and five other illicit drugs.

IF 1.8 4区医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Annals Of Work Exposures and Health Pub Date : 2024-08-08 DOI:10.1093/annweh/wxae048

Matthew Jeronimo, Molly Mastel, Jasleen Gill, Hugh Davies

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Abstract

With the increased provision of services by health authorities and community organizations allowing supervised inhalation of illicit substances comes concerns about the potential for secondhand exposure to the substances being used, whether in the adjacent community or to workers at the sites. In order to address community concerns surrounding secondhand illicit substance exposure and better protect harm reduction workers, a validated sampling and LC-MS/MS analysis method was developed for 6 illicit drugs: fentanyl, heroin, methamphetamine, cocaine, etizolam, and bromazolam. It was found that the filter used needed to be silanized to be made more inert and avoid loss of analyte due to degradation. Using the silanized filters, recoveries were good (>90%) and the collected samples were found to be stable at room temperature for 2 wk. The sampling volume validated was up to 960 L. The sensitivity and range of the method make it appropriate for short-term (15 min), full shift (8 h), or environmental sampling.

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验证测量芬太尼和其他五种非法药物的取样方法和液相色谱质谱分析方法。

随着卫生部门和社区组织越来越多地提供允许在监督下吸入非法药物的服务，人们开始担心无论是邻近社区还是现场工作人员都有可能二手接触到所使用的药物。为了解决社区对二手非法药物暴露的担忧，并更好地保护减低危害工作人员，我们针对 6 种非法药物（芬太尼、海洛因、甲基苯丙胺、可卡因、依替唑仑和溴唑仑）开发了一种经过验证的采样和 LC-MS/MS 分析方法。研究发现，所使用的过滤器需要经过硅烷化处理，以提高其惰性，避免因降解而造成分析物的损失。使用硅烷化过滤器后，回收率良好（大于 90%），收集的样品在室温下可稳定保存 2 周。该方法的灵敏度和范围使其适用于短期（15 分钟）、全班（8 小时）或环境采样。

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来源期刊

Annals Of Work Exposures and Health Medicine-Public Health, Environmental and Occupational Health

CiteScore

4.60

自引率

19.20%

发文量

期刊介绍： About the Journal Annals of Work Exposures and Health is dedicated to presenting advances in exposure science supporting the recognition, quantification, and control of exposures at work, and epidemiological studies on their effects on human health and well-being. A key question we apply to submission is, "Is this paper going to help readers better understand, quantify, and control conditions at work that adversely or positively affect health and well-being?" We are interested in high quality scientific research addressing: the quantification of work exposures, including chemical, biological, physical, biomechanical, and psychosocial, and the elements of work organization giving rise to such exposures; the relationship between these exposures and the acute and chronic health consequences for those exposed and their families and communities; populations at special risk of work-related exposures including women, under-represented minorities, immigrants, and other vulnerable groups such as temporary, contingent and informal sector workers; the effectiveness of interventions addressing exposure and risk including production technologies, work process engineering, and personal protective systems; policies and management approaches to reduce risk and improve health and well-being among workers, their families or communities; methodologies and mechanisms that underlie the quantification and/or control of exposure and risk. There is heavy pressure on space in the journal, and the above interests mean that we do not usually publish papers that simply report local conditions without generalizable results. We are also unlikely to publish reports on human health and well-being without information on the work exposure characteristics giving rise to the effects. We particularly welcome contributions from scientists based in, or addressing conditions in, developing economies that fall within the above scope.