Prognostic utility of the geriatric nutritional risk index for head and neck cancer: Systematic review and meta-analysis

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-06-09 DOI:10.1002/hed.27842

Yao-Te Tsai MD, Liang-Tseng Kuo MD, Yun-Ting Wang MD, Andrea De Vito PhD, Sheng-Po Hao MD, Ku-Hao Fang MD, Yi-Chan Lee MD, Kuan-Yin Chen DDS, Chia-Hsuan Lai MD, Yuan-Hsiung Tsai PhD, Ethan I. Huang PhD, Ming-Shao Tsai MD, Cheng-Ming Hsu PhD, Geng-He Chang PhD, Chih-Wei Luan MD

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Abstract

We conducted a systematic review of the literature to assess the potential prognostic utility of geriatric nutritional risk index (GNRI) for head and neck cancer (HNC). We selected studies and extracted data after searching the Cochrane Library, EMBASE, and PubMed databases. The associations between GNRI and survival outcomes were explored by calculating hazard ratios (HRs) and 95% confidence intervals (CIs) through a random-effects meta-analysis. We included 11 studies that involved 2887 patients with HNC. The combined HR demonstrated significant associations of low GNRI with unfavorable progression-free survival (HR = 1.87, 95% CI = 1.32–2.65, p < 0.001) and overall survival (HR = 3.04, 95% CI = 2.30–4.03, p < 0.001). The association between the GNRI and overall survival persisted across various subgroups. The GNRI could serve as a valuable prognostic biomarker for patients with HNC. Low GNRI scores are significantly associated with unfavorable survival outcomes.

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头颈癌老年营养风险指数的预后效用：系统回顾和荟萃分析。

我们对文献进行了系统性回顾，以评估老年营养风险指数（GNRI）对头颈癌（HNC）的潜在预后作用。我们检索了 Cochrane 图书馆、EMBASE 和 PubMed 数据库，筛选出研究并提取数据。通过随机效应荟萃分析计算危险比（HRs）和 95% 置信区间（CIs），探讨 GNRI 与生存结果之间的关系。我们共纳入了 11 项研究，涉及 2887 名 HNC 患者。综合 HR 显示，低 GNRI 与不利的无进展生存期有显著相关性（HR = 1.87，95% CI = 1.32-2.65，p

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.