Contrast-enhanced CT and PET-CT characteristics of primary tracheal lymphoepithelioma-like carcinoma: case series.

IF 4 2区医学 Q2 ONCOLOGY

Translational lung cancer research Pub Date : 2024-05-31 Epub Date: 2024-05-29 DOI:10.21037/tlcr-24-333

Qin Liu, Fanrui Zeng, Chongxiang Peng, Yuhua Lin, Qiong Wang, Qingsi Zeng

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引用次数: 0

Abstract

Background: Primary tracheal lymphoepithelioma-like carcinoma (LELC) is extremely rare, with only a few cases reported so far, and few studies have focused on the radiological features. This study aimed to investigate contrast-enhanced computed tomography (CECT) and positron emission tomography-computed tomography (PET-CT) presentations of primary tracheal LELC to improve diagnosis.

Methods: A retrospective analysis was conducted on the clinical and imaging data of 13 patients with confirmed primary tracheal LELC between December 2013 and August 2022. We analyzed the radiological profiles of lesions on the CECT and PET-CT images.

Results: In 92.3% (12/13) of the cases, primary tracheal LELC lesions predominantly occurred in the thoracic segment. They manifested as singular, wide-based, eccentric, irregular nodules, or exhibited mass-like thickening of the tracheal wall with invasive growth both internally and externally along the wall. The thickest dimension of the lesion ranged from 9 to 28 mm, affecting a length of 30.8±13.5 mm. Luminal stenosis was evident in all patients, with the narrowest point reaching a stenosis rate of 85%. Lesion margins were clear in 69.2% (9/13), indistinct in 23.1% (3/13), and unclear in 7.7% (1/13) of all cases. Among the patients, 92.3% (12/13) exhibited a relatively uniform density on CT plain scans, with a CT value of 44.5±7.8 Hounsfield units (HU). Enhancement scans revealed moderate to marked enhancement in 75% (9/12) of cases. In 2 cases undergoing PET-CT examination, lesion standardized uptake values (SUVs) were 4.4 and 5.1, whereas enlarged lymph node SUVs were 7.7 and 6.3, respectively. Mediastinal lymph node enlargement was observed in 8 patients (61.5%, 8/13), with a maximum short axis of 11.1±5.5 mm. After treatment, 9 out of 12 patients (75%) showed no evidence of distant metastasis upon CT re-examination.

Conclusions: Early detection of primary tracheal LELC allows for curative resection and may lead to a favorable prognosis. It presents with characteristic CT findings, and the utilization of PET-CT improves diagnosis and staging.

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原发性气管淋巴上皮瘤样癌的对比增强 CT 和 PET-CT 特征：病例系列。

背景：原发性气管淋巴上皮瘤样癌症（LELC）极为罕见，迄今仅有少数病例报道，且很少有研究关注其放射学特征。本研究旨在探讨原发性气管淋巴上皮瘤样癌的对比增强计算机断层扫描（CECT）和正电子发射计算机断层扫描（PET-CT）表现，以提高诊断率：我们对2013年12月至2022年8月期间确诊的13例原发性气管LELC患者的临床和影像学数据进行了回顾性分析。我们分析了CECT和PET-CT图像上病变的放射学特征：在92.3%（12/13）的病例中，原发性气管LELC病变主要发生在胸段。它们表现为单发、宽基底、偏心、不规则结节，或表现为气管壁肿块样增厚，并沿气管壁内部和外部侵袭性生长。病变最厚处为 9 至 28 毫米，影响长度为 30.8±13.5 毫米。所有患者的管腔均明显狭窄，最窄处的狭窄率达到 85%。在所有病例中，病变边缘清晰的占 69.2%（9/13），不清晰的占 23.1%（3/13），不清楚的占 7.7%（1/13）。其中，92.3%（12/13 例）的患者在 CT 平扫中显示出相对均匀的密度，CT 值为 44.5±7.8 Hounsfield 单位（HU）。增强扫描显示，75%的病例（9/12）呈中度至明显强化。在接受 PET-CT 检查的 2 个病例中，病灶的标准化摄取值（SUV）分别为 4.4 和 5.1，而肿大淋巴结的 SUV 分别为 7.7 和 6.3。8例患者（61.5%，8/13）观察到纵隔淋巴结肿大，最大短轴为11.1±5.5毫米。治疗后，12 例患者中有 9 例（75%）在 CT 复查中未发现远处转移的证据：结论：早期发现原发性气管 LELC 可进行根治性切除，并可获得良好的预后。结论：早期发现原发性气管 LELC 可进行根治性切除术，并可能带来良好的预后。它具有特征性的 CT 结果，PET-CT 的使用可改善诊断和分期。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Translational lung cancer research Medicine-Oncology

CiteScore

7.20

自引率

2.50%

发文量

137

期刊介绍： Translational Lung Cancer Research(TLCR, Transl Lung Cancer Res, Print ISSN 2218-6751; Online ISSN 2226-4477) is an international, peer-reviewed, open-access journal, which was founded in March 2012. TLCR is indexed by PubMed/PubMed Central and the Chemical Abstracts Service (CAS) Databases. It is published quarterly the first year, and published bimonthly since February 2013. It provides practical up-to-date information on prevention, early detection, diagnosis, and treatment of lung cancer. Specific areas of its interest include, but not limited to, multimodality therapy, markers, imaging, tumor biology, pathology, chemoprevention, and technical advances related to lung cancer.