Polyphenols-based intelligent oral barrier membranes for periodontal bone defect reconstruction.

IF 5.6 1区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS
Regenerative Biomaterials Pub Date : 2024-05-28 eCollection Date: 2024-01-01 DOI:10.1093/rb/rbae058
Enni Chen, Tianyou Wang, Zhiyuan Sun, Zhipeng Gu, Shimeng Xiao, Yi Ding
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引用次数: 0

Abstract

Periodontitis-induced periodontal bone defects significantly impact patients' daily lives. The guided tissue regeneration and guided bone regeneration techniques, which are based on barrier membranes, have brought hope for the regeneration of periodontal bone defects. However, traditional barrier membranes lack antimicrobial properties and cannot effectively regulate the complex oxidative stress microenvironment in periodontal bone defect areas, leading to unsatisfactory outcomes in promoting periodontal bone regeneration. To address these issues, our study selected the collagen barrier membrane as the substrate material and synthesized a novel barrier membrane (PO/4-BPBA/Mino@COL, PBMC) with an intelligent antimicrobial coating through a simple layer-by-layer assembly method, incorporating reactive oxygen species (ROS)-scavenging components, commercial dual-functional linkers and antimicrobial building blocks. Experimental results indicated that PBMC exhibited good degradability, hydrophilicity and ROS-responsiveness, allowing for the slow and controlled release of antimicrobial drugs. The outstanding antibacterial, antioxidant and biocompatibility properties of PBMC contributed to resistance to periodontal pathogen infection and regulation of the oxidative balance, while enhancing the migration and osteogenic differentiation of human periodontal ligament stem cells. Finally, using a rat periodontal bone defect model, the therapeutic effect of PBMC in promoting periodontal bone regeneration under infection conditions was confirmed. In summary, the novel barrier membranes designed in this study have significant potential for clinical application and provide a reference for the design of future periodontal regenerative functional materials.

用于牙周骨缺损重建的基于多酚的智能口腔屏障膜。
牙周炎引起的牙周骨缺损严重影响了患者的日常生活。以屏障膜为基础的引导组织再生和引导骨再生技术为牙周骨缺损的再生带来了希望。然而,传统的屏障膜缺乏抗菌性,不能有效调节牙周骨缺损区复杂的氧化应激微环境,导致促进牙周骨再生的效果不理想。为了解决这些问题,我们的研究选择了胶原蛋白屏障膜作为基底材料,并通过简单的逐层组装方法,结合活性氧(ROS)清除成分、商业双功能连接体和抗菌构建模块,合成了具有智能抗菌涂层的新型屏障膜(PO/4-BPBA/Mino@COL,PBMC)。实验结果表明,PBMC 具有良好的降解性、亲水性和对 ROS 的反应性,可以缓慢、可控地释放抗菌药物。PBMC 卓越的抗菌、抗氧化和生物相容性有助于抵抗牙周病原体感染和调节氧化平衡,同时还能促进人类牙周韧带干细胞的迁移和成骨分化。最后,利用大鼠牙周骨缺损模型证实了 PBMC 在感染条件下促进牙周骨再生的治疗效果。总之,本研究设计的新型屏障膜具有巨大的临床应用潜力,为未来牙周再生功能材料的设计提供了参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Regenerative Biomaterials
Regenerative Biomaterials Materials Science-Biomaterials
CiteScore
7.90
自引率
16.40%
发文量
92
审稿时长
10 weeks
期刊介绍: Regenerative Biomaterials is an international, interdisciplinary, peer-reviewed journal publishing the latest advances in biomaterials and regenerative medicine. The journal provides a forum for the publication of original research papers, reviews, clinical case reports, and commentaries on the topics relevant to the development of advanced regenerative biomaterials concerning novel regenerative technologies and therapeutic approaches for the regeneration and repair of damaged tissues and organs. The interactions of biomaterials with cells and tissue, especially with stem cells, will be of particular focus.
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