Skipping Breakfast and Progression of Chronic Kidney Disease in the General Japanese Population: The Iki City Epidemiological Study of Atherosclerosis and Chronic Kidney Disease (ISSA-CKD).

IF 2.3 4区医学 Q2 PERIPHERAL VASCULAR DISEASE

Kidney & blood pressure research Pub Date : 2024-01-01 Epub Date: 2024-06-07 DOI:10.1159/000539653

Koji Takahashi, Yori Inoue, Kazuhiro Tada, Hiroto Hiyamuta, Kenji Ito, Tetsuhiko Yasuno, Takashi Sakaguchi, Shiori Katsuki, Yukiko Shinohara, Chihiro Nohara, Shota Okutsu, Makiko Abe, Atsushi Satoh, Miki Kawazoe, Toshiki Maeda, Chikara Yoshimura, Shigeaki Mukoubara, Hisatomi Arima, Kosuke Masutani

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引用次数: 0

Abstract

Introduction: Breakfast-skipping habits are associated with adverse health outcomes including coronary heart disease, metabolic syndrome, and diabetes mellitus. However, it remains uncertain whether skipping breakfast affects chronic kidney disease (CKD) risk. This study aimed to examine the association between skipping breakfast and progression of CKD.

Methods: We retrospectively conducted a population-based cohort study using the data from the Iki City Epidemiological Study of Atherosclerosis and Chronic Kidney Disease (ISSA-CKD). Between 2008 and 2019, we included 922 participants aged 30 years or older who had CKD (estimated glomerular filtration rate <60 mL/min/1.73 m2 and/or proteinuria) at baseline. Breakfast skippers were defined as participants who skipped breakfast more than 3 times per week. The outcome was CKD progression defined as a decline of at least 30% in the estimated glomerular filtration rate (eGFR) from the baseline status. Cox proportional hazards models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for CKD progression, adjusted for other CKD risk factors.

Results: During a follow-up period with a mean of 5.5 years, CKD progression occurred in 60 (6.5%) participants. The incidence rate (per 1,000 person-years) of CKD progression was 21.5 in the breakfast-skipping group and 10.7 in the breakfast-eating group (p = 0.029), respectively. The multivariable-adjusted HR (95% CI) for CKD progression was 2.60 (95% CI: 1.29-5.26) for the breakfast-skipping group (p = 0.028) compared with the group eating breakfast. There were no clear differences in the association of skipping breakfast with CKD progression in subgroup analyses by sex, age, obesity, hypertension, diabetes mellitus, baseline eGFR, and baseline proteinuria.

Conclusion: Skipping breakfast was significantly associated with higher risk of CKD progression in the general Japanese population.

查看原文本刊更多论文

不吃早餐与日本普通人群慢性肾脏病的进展：Iki 市动脉粥样硬化和慢性肾脏病流行病学研究 (ISSA-CKD)。

简介：不吃早餐的习惯与冠心病、代谢综合征和糖尿病等不良健康后果有关：不吃早餐的习惯与冠心病、代谢综合征和糖尿病等不良健康后果有关。然而，不吃早餐是否会影响慢性肾脏病（CKD）的风险仍不确定。本研究旨在探讨不吃早餐与慢性肾脏病进展之间的关系：方法：我们回顾性地开展了一项基于人群的队列研究，使用的数据来自于Iki市动脉粥样硬化和慢性肾脏病流行病学研究（ISSA-CKD）。2008年至2019年期间，我们纳入了922名年龄在30岁或30岁以上、基线时患有慢性肾脏病（估计肾小球滤过率<60 mL/min/1.73m2和/或蛋白尿）的参与者。不吃早餐者是指每周不吃早餐超过 3 次的参与者。CKD进展是指eGFR比基线下降至少30%。采用 Cox 比例危险模型计算 CKD 进展的危险比（HRs）和 95% 置信区间（CIs），并对其他 CKD 危险因素进行调整：在平均 5.5 年的随访期间，有 60 名参与者（6.5%）出现了 CKD 进展。不吃早餐组和吃早餐组的 CKD 进展发生率（每千人年）分别为 21.5 和 10.7（P=0.029）。与吃早餐组相比，不吃早餐组的 CKD 病情发展的多变量调整 HR（95% CI）为 2.60（95% CI 1.29-5.26）（p=0.028）。在按性别、年龄、肥胖、高血压、糖尿病、基线 eGFR 和基线蛋白尿进行的亚组分析中，不吃早餐与 CKD 进展的关系没有明显差异：结论：在日本普通人群中，不吃早餐与较高的慢性肾脏病进展风险明显相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Kidney & blood pressure research 医学-泌尿学与肾脏学

CiteScore

4.80

自引率

3.60%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal comprises both clinical and basic studies at the interface of nephrology, hypertension and cardiovascular research. The topics to be covered include the structural organization and biochemistry of the normal and diseased kidney, the molecular biology of transporters, the physiology and pathophysiology of glomerular filtration and tubular transport, endothelial and vascular smooth muscle cell function and blood pressure control, as well as water, electrolyte and mineral metabolism. Also discussed are the (patho)physiology and (patho) biochemistry of renal hormones, the molecular biology, genetics and clinical course of renal disease and hypertension, the renal elimination, action and clinical use of drugs, as well as dialysis and transplantation. Featuring peer-reviewed original papers, editorials translating basic science into patient-oriented research and disease, in depth reviews, and regular special topic sections, ''Kidney & Blood Pressure Research'' is an important source of information for researchers in nephrology and cardiovascular medicine.