Magnetic Resonance Elastography of Anterior Mediastinal Tumors

IF 3.3 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Magnetic Resonance Imaging Pub Date : 2024-06-10 DOI:10.1002/jmri.29481

Lina Zhou MD, Qin Peng MD, Wei Tang MD, Ning Wu MD, Lin Yang MD, Linlin Qi MD, Jiang Li MD, Yao Huang MD

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引用次数: 0

Abstract

Background

Preoperative differentiation of the types of mediastinal tumors is essential. Magnetic resonance (MR) elastography potentially provides a noninvasive method to assess the classification of mediastinal tumor subtypes.

Purpose

To evaluate the use of MR elastography in anterior mediastinal masses and to characterize the mechanical properties of tumors of different subtypes.

Study Type

Prospective.

Subjects

189 patients with anterior mediastinal tumors (AMTs) confirmed by histopathology (62 thymomas, 53 thymic carcinomas, 57 lymphomas, and 17 germ cell tumors).

Field Strength/Sequence

A gradient echo-based 2D MR elastography sequence and a diffusion-weighted imaging (DWI) sequence at 3.0 T.

Assessment

Stiffness and apparent diffusion coefficients (ADC) were measured in AMTs using MR elastography-derived elastograms and DWI-derived ADC maps, respectively. The aim of this study is to identify whether MR elastography can differentiate between the histological subtypes of ATMs.

Statistical Tests

One-way analysis of variance (ANOVA), two-way ANOVA, Pearson's linear correlation coefficient (r), receiver operating characteristic (ROC) curve analysis; P < 0.05 was considered significant.

Results

Lymphomas had significantly lower stiffness than other AMTs (4.0 ± 0.63 kPa vs. 4.8 ± 1.39 kPa). The mean stiffness of thymic carcinomas was significantly higher than that of other AMTs (5.6 ± 1.41 kPa vs. 4.2 ± 0.94 kPa). Using a cutoff value of 5.0 kPa, ROC analysis showed that lymphomas could be differentiated from other AMTs with an accuracy of 59%, sensitivity of 97%, and specificity of 38%. Using a cutoff value of 5.1 kPa, thymic carcinomas could be differentiated from other AMTs with an accuracy of 84%, sensitivity of 67%, and specificity of 90%. However, there was an overlap in the stiffness values of individual thymomas (4.2 ± 0.71; 3.9–4.5), thymic carcinomas (5.6 ± 1.41; 5.0–6.1), lymphomas (4.0 ± 0.63; 3.8–4.2), and germ cell tumors (4.5 ± 1.79; 3.3–5.6).

Data Conclusion

MR elastography-derived stiffness may be used to evaluate AMTs of various histologies.

Level of Evidence

Technical Efficacy

Stage 2.

查看原文本刊更多论文

前纵隔肿瘤的磁共振弹性成像。

背景：术前区分纵隔肿瘤的类型至关重要。目的：评估磁共振弹性成像在前纵隔肿块中的应用，并描述不同亚型肿瘤的机械特性：研究类型：前瞻性：189名经组织病理学确诊的前纵隔肿瘤（AMT）患者（62例胸腺瘤、53例胸腺癌、57例淋巴瘤和17例生殖细胞瘤）：场强/序列：基于梯度回波的二维磁共振弹性成像序列和3.0 T的扩散加权成像（DWI）序列：分别使用磁共振弹性成像生成的弹性图和 DWI 生成的 ADC 图测量 AMT 的硬度和表观扩散系数（ADC）。本研究旨在确定磁共振弹性成像能否区分ATMs的组织学亚型：单因素方差分析（ANOVA）、双因素方差分析、皮尔逊线性相关系数（r）、接收者操作特征曲线（ROC）分析；P 结果：淋巴瘤的硬度明显低于其他AMT（4.0 ± 0.63 kPa vs. 4.8 ± 1.39 kPa）。胸腺癌的平均硬度明显高于其他AMT（5.6 ± 1.41 kPa vs. 4.2 ± 0.94 kPa）。ROC 分析显示，以 5.0 kPa 为临界值，淋巴瘤与其他 AMT 的鉴别准确率为 59%，灵敏度为 97%，特异性为 38%。以 5.1 kPa 为临界值，胸腺癌与其他 AMT 的鉴别准确率为 84%，灵敏度为 67%，特异性为 90%。然而，个别胸腺瘤（4.2 ± 0.71；3.9-4.5）、胸腺癌（5.6 ± 1.41；5.0-6.1）、淋巴瘤（4.0 ± 0.63；3.8-4.2）和生殖细胞瘤（4.5 ± 1.79；3.3-5.6）的硬度值存在重叠：数据结论：MR弹性成像衍生的硬度可用于评估不同组织学的AMT：4：技术疗效：证据级别：4：技术疗效：第二阶段。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Magnetic Resonance Imaging 医学-核医学

CiteScore

9.70

自引率

6.80%

发文量

494

审稿时长

2 months

期刊介绍： The Journal of Magnetic Resonance Imaging (JMRI) is an international journal devoted to the timely publication of basic and clinical research, educational and review articles, and other information related to the diagnostic applications of magnetic resonance.