Cohesin - bridging the gap among gene transcription, genome stability, and human diseases.

IF 3.5 4区生物学 Q1 Biochemistry, Genetics and Molecular Biology

FEBS Letters Pub Date : 2024-06-09 DOI:10.1002/1873-3468.14949

Maddalena Di Nardo, Antonio Musio

引用次数: 0

Abstract

The intricate landscape of cellular processes governing gene transcription, chromatin organization, and genome stability is a fascinating field of study. A key player in maintaining this delicate equilibrium is the cohesin complex, a molecular machine with multifaceted roles. This review presents an in-depth exploration of these intricate connections and their significant impact on various human diseases.

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凝聚素--基因转录、基因组稳定性和人类疾病之间的桥梁。

管理基因转录、染色质组织和基因组稳定性的细胞过程错综复杂，是一个引人入胜的研究领域。维持这一微妙平衡的关键角色是凝聚素复合体，它是一种具有多方面作用的分子机器。本综述深入探讨了这些错综复杂的联系及其对各种人类疾病的重大影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

FEBS Letters 生物-生化与分子生物学

CiteScore

7.00

自引率

2.90%

发文量

303

审稿时长

1.0 months

期刊介绍： FEBS Letters is one of the world''s leading journals in molecular biology and is renowned both for its quality of content and speed of production. Bringing together the most important developments in the molecular biosciences, FEBS Letters provides an international forum for Minireviews, Research Letters and Hypotheses that merit urgent publication.