Malassezia specific IgE in head and neck dermatitis of eczema: A systematic review & meta-analysis

IF 3.5 3区 医学 Q1 DERMATOLOGY
Hui Xin See Tow, Yik Weng Yew
{"title":"Malassezia specific IgE in head and neck dermatitis of eczema: A systematic review & meta-analysis","authors":"Hui Xin See Tow,&nbsp;Yik Weng Yew","doi":"10.1111/exd.15108","DOIUrl":null,"url":null,"abstract":"<p>Head and neck atopic dermatitis (HNAD) is a subtype of atopic dermatitis (AD), a common inflammatory skin condition with a distinctive clinical appearance. <i>Malassezia</i> spp., a predominant skin yeast, is considered to exacerbate HNAD. In this study, we investigate the prevalence of <i>Malassezia</i>-specific IgE among HNAD patients. A comprehensive search was performed for observational studies analysing the association between <i>Malassezia</i>-specific IgE and HNAD. This study was performed according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses 2020 checklist and quality was assessed via the Newcastle-Ottawa Quality Assessment Scale (NOS). Fourteen observational studies (840 patients) were included in the analysis. 58% of HNAD patients were male (95% CI: 45.2–69.7). Overall prevalence of <i>Malassezia</i>-specific IgE among HNAD patients was 79.3% (95% CI: 57.5–91.5). Prevalence of <i>Malassezia-</i>specific IgE among HNAD patients varied significantly between geographical regions (<i>p</i> = 0.0441), with 88% in non-Asian regions (95% CI: 61.06–97.17) and 54.73% in Asian regions (95% CI: 34.36–73.63). <i>Malassezia</i>-specific IgE prevalence among HNAD patients varied significantly among studies of higher and lower NOS quality score (<i>p</i> = 0.0386), with 95.42% in studies with NOS ≥7 (95% CI: 63.54–99.60) and 58.05% in studies with NOS &lt;7 (95% CI: 41.44–73.01). <i>Malassezia</i>-specific IgE prevalence among HNAD patients did not vary significantly between more and less predominant <i>Malassezia</i> species (<i>p</i> = 0.1048). <i>Malassezia</i> spp. plays a crucial role in the pathogenesis of HNAD, and IgE anti-<i>Malassezia</i> antibodies appeared to be a common marker for HNAD. Understanding the pathophysiology of <i>Malassezia</i> in HNAD can help develop more targeted therapeutic approaches in managing AD.</p>","PeriodicalId":12243,"journal":{"name":"Experimental Dermatology","volume":null,"pages":null},"PeriodicalIF":3.5000,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimental Dermatology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/exd.15108","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Head and neck atopic dermatitis (HNAD) is a subtype of atopic dermatitis (AD), a common inflammatory skin condition with a distinctive clinical appearance. Malassezia spp., a predominant skin yeast, is considered to exacerbate HNAD. In this study, we investigate the prevalence of Malassezia-specific IgE among HNAD patients. A comprehensive search was performed for observational studies analysing the association between Malassezia-specific IgE and HNAD. This study was performed according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses 2020 checklist and quality was assessed via the Newcastle-Ottawa Quality Assessment Scale (NOS). Fourteen observational studies (840 patients) were included in the analysis. 58% of HNAD patients were male (95% CI: 45.2–69.7). Overall prevalence of Malassezia-specific IgE among HNAD patients was 79.3% (95% CI: 57.5–91.5). Prevalence of Malassezia-specific IgE among HNAD patients varied significantly between geographical regions (p = 0.0441), with 88% in non-Asian regions (95% CI: 61.06–97.17) and 54.73% in Asian regions (95% CI: 34.36–73.63). Malassezia-specific IgE prevalence among HNAD patients varied significantly among studies of higher and lower NOS quality score (p = 0.0386), with 95.42% in studies with NOS ≥7 (95% CI: 63.54–99.60) and 58.05% in studies with NOS <7 (95% CI: 41.44–73.01). Malassezia-specific IgE prevalence among HNAD patients did not vary significantly between more and less predominant Malassezia species (p = 0.1048). Malassezia spp. plays a crucial role in the pathogenesis of HNAD, and IgE anti-Malassezia antibodies appeared to be a common marker for HNAD. Understanding the pathophysiology of Malassezia in HNAD can help develop more targeted therapeutic approaches in managing AD.

Abstract Image

头颈部皮炎湿疹中的马拉色菌特异性 IgE:系统回顾与荟萃分析。
头颈部特应性皮炎(HNAD)是特应性皮炎(AD)的一种亚型,是一种常见的炎症性皮肤病,具有独特的临床表现。马拉色菌是一种主要的皮肤酵母菌,被认为会加重 HNAD。在本研究中,我们调查了 HNAD 患者中马拉色菌特异性 IgE 的患病率。我们对分析马拉色菌特异性 IgE 与 HNAD 之间关系的观察性研究进行了全面检索。该研究根据《2020 年系统综述和荟萃分析首选报告项目》(Preferred Reporting Items for Systematic Review and Meta-Analyses 2020)清单进行,并通过纽卡斯尔-渥太华质量评估量表(Newcastle-Ottawa Quality Assessment Scale,NOS)进行质量评估。分析中纳入了 14 项观察性研究(840 名患者)。58%的HNAD患者为男性(95% CI:45.2-69.7)。HNAD 患者中马拉色菌特异性 IgE 的总体患病率为 79.3%(95% CI:57.5-91.5)。不同地理区域的 HNAD 患者马拉色菌特异性 IgE 患病率差异显著(p = 0.0441),非亚洲地区为 88%(95% CI:61.06-97.17),亚洲地区为 54.73%(95% CI:34.36-73.63)。在 NOS 质量得分较高和较低的研究中,HNAD 患者马拉色菌特异性 IgE 患病率有显著差异(p = 0.0386),NOS ≥7 的研究中患病率为 95.42%(95% CI:63.54-99.60),NOS ≥8 的研究中患病率为 58.05%(95% CI:63.54-99.60)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Experimental Dermatology
Experimental Dermatology 医学-皮肤病学
CiteScore
6.70
自引率
5.60%
发文量
201
审稿时长
2 months
期刊介绍: Experimental Dermatology provides a vehicle for the rapid publication of innovative and definitive reports, letters to the editor and review articles covering all aspects of experimental dermatology. Preference is given to papers of immediate importance to other investigators, either by virtue of their new methodology, experimental data or new ideas. The essential criteria for publication are clarity, experimental soundness and novelty. Letters to the editor related to published reports may also be accepted, provided that they are short and scientifically relevant to the reports mentioned, in order to provide a continuing forum for discussion. Review articles represent a state-of-the-art overview and are invited by the editors.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信