Experimental study of the biological properties of nmHA-SiO₂ fiber materials prepared by electrospinning technology.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-07-31 Epub Date: 2024-06-07 DOI:10.4012/dmj.2023-274

Wenyun Zhang, Yuhan Zheng, Cheng Yang, Zhimin Yu, Yuan Zhao, Li Yang, Yanbo Li, Qing Liu, Chongyan Xu, Jun Su, Tingting Yan

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引用次数: 0

Abstract

To study the biocompatibility of nanohydroxyapatite (nmHA)-SiO₂ fiber material and its efficacy in guided bone regeneration. ① The cytotoxicity of the nmHA-SiO₂ fiber material to MC3T3-E1 cells was determined by CCK-8 assay. The adhesion of cells on the surface of the material was observed. ② Bone defects were prepared in the skull of three groups of New Zealand white rabbits. The following treatments were administered: implantation of nmHA-SiO₂, implantation of Bio-Oss, and no treatment. The defects were then covered with nmHA-SiO₂ membrane or Hai'ao oral repair membrane. Animal samples were analyzed by gross observation, micro-computed tomography, hematoxylin-eosin staining and Masson staining. The data were statistically analyzed by multivariate analysis of variance to evaluate the repair of bone defects. ① The nmHA-SiO₂ fiber material has suitable biocompatibility. ② The nmHA-SiO₂ fiber material performed more effectively as a barrier membrane than other bone substitute materials in GBR model rabbits.

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电纺丝技术制备的 nmHA-SiO2 纤维材料生物特性的实验研究。

研究纳米羟基磷灰石（nmHA）-SiO2 纤维材料的生物相容性及其在引导骨再生中的功效。通过 CCK-8 试验测定纳米羟基磷灰石-二氧化硅纤维材料对 MC3T3-E1 细胞的细胞毒性。观察了细胞在材料表面的粘附情况。在三组新西兰白兔的头骨上制备骨缺损。处理方法如下：植入 nmHA-SiO2、植入 Bio-Oss 和不处理。然后用 nmHA-SiO2 膜或海奥口腔修复膜覆盖缺损处。通过大体观察、微型计算机断层扫描、苏木精-伊红染色和马森染色对动物样本进行分析。采用多元方差分析对数据进行统计分析，以评估骨缺损的修复效果。nmHA-SiO2 纤维材料具有合适的生物相容性。在 GBR 模型兔中，nmHA-SiO2 纤维材料作为屏障膜的效果优于其他骨替代材料。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.