Diabetes and risk of hospitalisation due to infection in northeastern Thailand: Retrospective cohort study using population-based healthcare service data

IF 3.2 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Diabetic Medicine Pub Date : 2024-06-09 DOI:10.1111/dme.15378

Pimnara Peerawaranun, Wirichada Pan-ngum, Viriya Hantrakun, Sarah H. Wild, Susanna Dunachie, Parinya Chamnan

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引用次数: 0

Abstract

Background

Population-based studies describing the association between diabetes and increased risk of infection have largely been based in high-income countries. There is limited information describing the burden of infectious disease attributable to diabetes in low and middle-income countries. This study aimed to describe the burden and risk of infectious disease hospitalisation in people with diabetes compared to those without diabetes in northeastern Thailand.

Methods

In a retrospective cohort study using electronic health record data for 2012–2018 for 3.8 million people aged ≥20 years in northeastern Thailand, hospitalisation rates for any infectious diseases (ICD-10 codes A00-B99) were estimated and negative binomial regression used to estimate rate ratios (RR) for the association between diabetes and infectious disease hospitalisation adjusted for age, sex and area of residence.

Results

In this study, 164,177 people had a diagnosis of diabetes mellitus at any point over the study period. Infectious disease hospitalisation rates per 1000 person-years (95%CI) were 71.8 (70.9, 72.8), 27.7 (27.1, 28.3) and 7.5 (7.5, 7.5) for people with prevalent diabetes, incident diabetes and those without diabetes respectively. Diabetes was associated with a 4.6-fold higher risk of infectious disease hospitalisation (RR (95% CI) 4.59 (4.52, 4.66)). RRs for infectious disease hospitalisation were 3.38 (3.29, 3.47) for people with diabetes managed by lifestyle alone and 5.29 (5.20, 5.39) for people receiving prescriptions for diabetes drugs.

Conclusions

In this Thai population, diabetes was associated with substantially increased risk of hospitalisation due to infectious diseases and people with diabetes who were on pharmacological treatment had a higher risk than those receiving lifestyle modification advice alone.

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泰国东北部的糖尿病与感染住院风险：利用基于人口的医疗服务数据进行的回顾性队列研究。

背景：描述糖尿病与感染风险增加之间关系的人群研究主要基于高收入国家。在中低收入国家，有关糖尿病导致的传染病负担的信息非常有限。本研究旨在描述泰国东北部地区糖尿病患者与非糖尿病患者的传染病住院负担和风险：方法：在一项回顾性队列研究中，使用泰国东北部380万年龄≥20岁人群2012-2018年的电子健康记录数据，估算了任何传染病（ICD-10代码A00-B99）的住院率，并使用负二项回归估算了糖尿病与传染病住院之间的比率比（RR），并对年龄、性别和居住地区进行了调整：在这项研究中，有 164 177 人在研究期间的任何时候被诊断出患有糖尿病。糖尿病患者、糖尿病偶发患者和无糖尿病患者的传染病住院率分别为 71.8（70.9，72.8）、27.7（27.1，28.3）和 7.5（7.5，7.5）/1000 人/年（95%CI）。糖尿病患者感染传染病住院的风险高出 4.6 倍（RR (95% CI) 4.59 (4.52, 4.66)）。仅通过生活方式控制的糖尿病患者感染传染病住院的RR为3.38（3.29，3.47），接受糖尿病药物处方的患者感染传染病住院的RR为5.29（5.20，5.39）：在泰国的这一人群中，糖尿病患者因传染病住院的风险大大增加，接受药物治疗的糖尿病患者比只接受生活方式调整建议的患者风险更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetic Medicine 医学-内分泌学与代谢

CiteScore

7.20

自引率

5.70%

发文量

229

审稿时长

3-6 weeks

期刊介绍： Diabetic Medicine, the official journal of Diabetes UK, is published monthly simultaneously, in print and online editions. The journal publishes a range of key information on all clinical aspects of diabetes mellitus, ranging from human genetic studies through clinical physiology and trials to diabetes epidemiology. We do not publish original animal or cell culture studies unless they are part of a study of clinical diabetes involving humans. Categories of publication include research articles, reviews, editorials, commentaries, and correspondence. All material is peer-reviewed. We aim to disseminate knowledge about diabetes research with the goal of improving the management of people with diabetes. The journal therefore seeks to provide a forum for the exchange of ideas between clinicians and researchers worldwide. Topics covered are of importance to all healthcare professionals working with people with diabetes, whether in primary care or specialist services. Surplus generated from the sale of Diabetic Medicine is used by Diabetes UK to know diabetes better and fight diabetes more effectively on behalf of all people affected by and at risk of diabetes as well as their families and carers.”