Inhibiting the activation of enteric glial cells alleviates intestinal inflammation and comorbid anxiety- and depressive-like behaviors in the ulcerative colitis mice

IF 4.4 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Yan Li , Yan Wang , Qian Sun , Meng-Ying Li , Jia-Zhou Xu , Yun-Qing Li , Hua Zhang
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引用次数: 0

Abstract

Ulcerative colitis (UC) is a common inflammatory bowel disease with a complex origin in clinical settings. It is frequently accompanied by negative emotional responses, including anxiety and depression. Enteric glial cells (EGCs) are important components of the gut-brain axis and are involved in the development of the enteric nervous system (ENS), intestinal neuroimmune, and regulation of intestinal motor functions. Since there is limited research encompassing the regulatory function of EGCs in anxiety- and depression-like behaviors induced by UC, this study aims to reveal their regulatory role in such behaviors and associated intestinal inflammation. This study applied morphological, molecular biological, and behavioral methods to observe the morphological and functional changes of EGCs in UC mice. The results indicated a significant activation of EGCs in the ENS of dextran sodium sulfate -induced UC mice. This activation was evidenced by morphological alterations, such as elongation or terminal swelling of processes. Besides EGCs activation, UC mice exhibited significantly elevated expression levels of pro-inflammatory cytokines in the peripheral blood, accompanied by anxiety- and depression-like behaviors. The inhibition of EGCs activity within the ENS can ameliorate the anxiety- and depression-like behaviors caused by UC. Our data suggest that UC and its resulting behaviors may be related to the activation of EGCs within the ENS. Moreover, the modulation of intestinal inflammation through inhibition of EGCs activation emerges as a promising clinical approach for alleviating UC-induced anxiety- and depression-like behaviors.

抑制肠胶质细胞的活化可减轻溃疡性结肠炎小鼠的肠道炎症以及合并的焦虑和抑郁样行为。
溃疡性结肠炎(UC)是一种常见的炎症性肠病,在临床上病因复杂。它经常伴有负面情绪反应,包括焦虑和抑郁。肠胶质细胞(EGCs)是肠道-大脑轴的重要组成部分,参与肠道神经系统(ENS)的发育、肠道神经免疫和肠道运动功能的调节。由于有关EGCs在UC诱导的焦虑和抑郁样行为中的调节功能的研究有限,本研究旨在揭示EGCs在此类行为和相关肠道炎症中的调节作用。本研究采用形态学、分子生物学和行为学方法观察了EGCs在UC小鼠体内的形态和功能变化。结果表明,右旋糖酐硫酸钠诱导的UC小鼠的ENS中的EGCs被明显激活。这种活化表现为形态学上的改变,如过程的伸长或末端肿胀。除EGCs活化外,UC小鼠外周血中促炎细胞因子的表达水平也明显升高,并伴有焦虑和抑郁样行为。抑制 ENS 中 EGCs 的活性可以改善 UC 引起的焦虑和抑郁行为。我们的数据表明,UC 及其导致的行为可能与 ENS 中 EGCs 的激活有关。此外,通过抑制EGCs的活化来调节肠道炎症是一种很有前景的临床方法,可用于缓解UC引起的焦虑和抑郁样行为。
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来源期刊
Neurochemistry international
Neurochemistry international 医学-神经科学
CiteScore
8.40
自引率
2.40%
发文量
128
审稿时长
37 days
期刊介绍: Neurochemistry International is devoted to the rapid publication of outstanding original articles and timely reviews in neurochemistry. Manuscripts on a broad range of topics will be considered, including molecular and cellular neurochemistry, neuropharmacology and genetic aspects of CNS function, neuroimmunology, metabolism as well as the neurochemistry of neurological and psychiatric disorders of the CNS.
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