Photobiomodulation minimizes taste changes during hematopoietic cell transplantation: A randomized clinical trial

IF 2 3区物理与天体物理 Q3 BIOCHEMICAL RESEARCH METHODS

Journal of Biophotonics Pub Date : 2024-06-08 DOI:10.1002/jbio.202400095

Mariana Henriques Ferreira, Letícia Mello Bezinelli, Fernanda de Paula Eduardo, Andrea Z. Pereira, Nelson Hamerschlak, Luciana Corrêa

{"title":"Photobiomodulation minimizes taste changes during hematopoietic cell transplantation: A randomized clinical trial","authors":"Mariana Henriques Ferreira, Letícia Mello Bezinelli, Fernanda de Paula Eduardo, Andrea Z. Pereira, Nelson Hamerschlak, Luciana Corrêa","doi":"10.1002/jbio.202400095","DOIUrl":null,"url":null,"abstract":"Prevention and treatment protocols for taste changes observed during hematopoietic cell transplantation (HCT) are not well-established. The purpose of this study was to assess the efficacy of photobiomodulation (PBM) in relieving taste changes and preventing lingual papillae atrophy. HCT patients received PBM (n = 42) on the tongue dorsum using an InGaAIP laser (660 nm, 100 mW, 1.1 W/cm2, 8.8 J/cm2). During the HCT conditioning (T0), severe neutropenia (T1), and after neutrophil engraftment (T2), taste acuity for sweet, bitter, sour, and salty solutions, and clinical appearance of lingual papillae were compared with those of a placebo group (n = 43). PBM significantly reduced hypogeusia, ageusia, and parageusia at T1 and T2, and also successfully prevented papillae atrophy during all the analyzed HCT periods. In conclusion, PBM enhanced taste acuity during HCT. The decrease in papillae atrophy indicated a potential regenerative effect of this therapy on tongue mucosa.","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":null,"pages":null},"PeriodicalIF":2.0000,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Biophotonics","FirstCategoryId":"101","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jbio.202400095","RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}

引用次数: 0

Abstract

Prevention and treatment protocols for taste changes observed during hematopoietic cell transplantation (HCT) are not well-established. The purpose of this study was to assess the efficacy of photobiomodulation (PBM) in relieving taste changes and preventing lingual papillae atrophy. HCT patients received PBM (n = 42) on the tongue dorsum using an InGaAIP laser (660 nm, 100 mW, 1.1 W/cm², 8.8 J/cm²). During the HCT conditioning (T0), severe neutropenia (T1), and after neutrophil engraftment (T2), taste acuity for sweet, bitter, sour, and salty solutions, and clinical appearance of lingual papillae were compared with those of a placebo group (n = 43). PBM significantly reduced hypogeusia, ageusia, and parageusia at T1 and T2, and also successfully prevented papillae atrophy during all the analyzed HCT periods. In conclusion, PBM enhanced taste acuity during HCT. The decrease in papillae atrophy indicated a potential regenerative effect of this therapy on tongue mucosa.

Abstract Image

查看原文本刊更多论文

光生物调节可将造血细胞移植期间的味觉变化降至最低：随机临床试验。

针对造血细胞移植（HCT）过程中观察到的味觉变化的预防和治疗方案尚不完善。本研究旨在评估光生物调控（PBM）在缓解味觉变化和预防舌乳头萎缩方面的疗效。HCT 患者使用 InGaAIP 激光器（660 nm、100 mW、1.1 W/cm2、8.8 J/cm2）在舌背上进行光生物调节（n = 42）。在 HCT 调理期间（T0）、严重中性粒细胞减少期（T1）和中性粒细胞移植后（T2），对甜、苦、酸和咸溶液的味觉敏锐度以及舌乳头的临床表现与安慰剂组（n = 43）进行了比较。在 T1 和 T2 期，PBM 能明显减轻舌下肌无力、老化肌无力和副舌肌无力，还能在所有分析的 HCT 期成功防止舌乳头萎缩。总之，PBM 提高了 HCT 期间的味觉敏锐度。乳头萎缩的减少表明这种疗法对舌粘膜具有潜在的再生作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Biophotonics 生物-生化研究方法

CiteScore

5.70

自引率

7.10%

发文量

248

审稿时长

1 months

期刊介绍： The first international journal dedicated to publishing reviews and original articles from this exciting field, the Journal of Biophotonics covers the broad range of research on interactions between light and biological material. The journal offers a platform where the physicist communicates with the biologist and where the clinical practitioner learns about the latest tools for the diagnosis of diseases. As such, the journal is highly interdisciplinary, publishing cutting edge research in the fields of life sciences, medicine, physics, chemistry, and engineering. The coverage extends from fundamental research to specific developments, while also including the latest applications.