Multimodal Imaging of Optic Nerve Head in Retinitis Pigmentosa.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-08-01 Epub Date: 2024-06-08 DOI:10.1080/08820538.2024.2363849

Naoko Wada, Seiji Takagi, Akiko Yoshikawa, Takashi Itokawa, Takahiro Maruyama, Yuichi Hori

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引用次数: 0

Abstract

Background: A pallor optic nerve head (ONH) is one of the three features of retinitis pigmentosa (RP). This study aimed to assess the ONH prospectively by color tone, presence of hyper-reflective tissue, blood flow, retinal nerve fiber layer (RNFL) thickness, ganglion cell complex (GCC) and investigate the change in these parameters with and without ONH pallor.

Methods: The presence of ONH pallor was assessed by three independent examiners through careful examination using fundus photographs. The presence of a hyper-reflective structure on the ONH was carefully evaluated using a volume scan optical coherence tomography (OCT). RNFL thickness and ellipsoid zone (EZ) width around the macula were also evaluated by OCT. Laser speckle flowgraphy was used to measure the mean blur rate of the entire ONH area, which was subsequently divided into the vessel area (MV) and tissue area (MT).

Results: Twenty-eight eyes of 28 patients with RP (55.4 ± 16.23 years of age) were included. The pale ONH was observed in 10 (35%) eyes. Hyper-reflective structures were observed in seven (25%) eyes. No significant correlation was found between the pale ONH and the presence of a hyper-reflective structure (Pearson's chi-squared test, p = .364). The average of the ONH area, MV, and MT was 8.65 ± 3.08 AU, 17.81 ± 7.54 AU, and 6.4 ± 2.66 AU, respectively, which significantly decreased in patients with pallor ONH (all p < .05). The global RNFL thickness was 73.54 ± 18.82 μm. The nasal and superior quadrants and global RNFL thickness in patients with a pale ONH were significantly thinner than in patients without a pale ONH (all p < .05). The global and superior and inferior GCC thickness in patients with a pale ONH were significantly thinner than in patients without a pale ONH(all p < .05).There was no difference in the EZ width between patients with and without a pale ONH (p = .107).

Conclusion: We conducted multiple assessments of the ONH in RP patients and investigated its clinical significance. Our findings suggest that ONH pallor may indicate a comprehensive change that emerges alongside the progression of retinal degeneration in RP.

Trial registration: This trial was retrospectively registered in the UMIN Clinical Trial Registry (UMIN ID: 000048168).

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视网膜色素变性视神经头的多模态成像

背景：视神经头（ONH）苍白是视网膜色素变性（RP）的三大特征之一。本研究旨在通过色调、是否存在高反射组织、血流量、视网膜神经纤维层（RNFL）厚度、神经节细胞复合体（GCC）对视神经头进行前瞻性评估，并研究视神经头苍白与否这些参数的变化：由三位独立的检查人员使用眼底照片进行仔细检查，评估是否存在视网膜上皮苍白。使用容积扫描光学相干断层扫描（OCT）仔细评估 ONH 是否存在高反射结构。OCT 还对黄斑周围的 RNFL 厚度和椭圆形区（EZ）宽度进行了评估。激光斑点血流图用于测量整个视网膜上皮区域的平均模糊率，随后将其分为血管区域（MV）和组织区域（MT）：共纳入 28 名 RP 患者（55.4 ± 16.23 岁）的 28 只眼睛。10只眼睛（35%）观察到苍白的ONH。7只眼睛（25%）观察到高反射结构。在苍白的视网膜上皮和高反射结构的存在之间没有发现明显的相关性（Pearson's chi-squared test，p = .364）。ONH面积、MV和MT的平均值分别为8.65 ± 3.08 AU、17.81 ± 7.54 AU和6.4 ± 2.66 AU，在ONH苍白的患者中明显下降（所有P P P = .107）：我们对RP患者的ONH进行了多重评估，并研究了其临床意义。我们的研究结果表明，ONH苍白可能是RP患者视网膜变性进展过程中出现的一种综合变化：本试验在UMIN临床试验注册中心进行了回顾性注册（UMIN ID：000048168）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.