Application of capsaicin and calcium phosphate-loaded MOF system for tumor therapy involving calcium overload

IF 4.2 2区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Yuan Gao MSc , Jun Wang PhD , Weiwei Zhang PhD , Fei Ge PhD , Wanzhen Li PhD , Feiyang Xu MSc , Ting Cui MSc , Xing Li MSc , Kai Yang PhD , Yugui Tao MSc
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引用次数: 0

Abstract

Calcium overload therapy refers to the condition of intracellular Ca2+ overload, which causes mitochondrial damage and leads to the uncontrolled release of apoptotic factors into the cytoplasm through the open mitochondrial permeability pore. Based on this, it is playing an increasingly important role in the field of oncology due to its good efficacy and small side effects. However, the regulation of calcium homeostasis by cancer cells themselves, insufficient calcium ions (Ca2+) in tumor sites and low efficiency of calcium entering tumor have limited its efficacy, resulting in unsatisfactory therapeutic effect. Therefore, a novel CAP/BSA@TCP-ZIF-8 nanoparticle drug carrier system was constructed that can provide Ca2+ from exogenous sources for pH-controlled degradation and drug release at the same time. Both in vivo and in vitro experiments have proved that the nanomaterial can activate TRPV1 channels and provide exogenous Ca2+ to cause Ca2+ overload and apoptosis, thus achieving anti-tumor effects.

Abstract Image

将辣椒素和磷酸钙负载的 MOF 系统应用于涉及钙超载的肿瘤治疗。
钙超载治疗是指在细胞内 Ca2+ 超载的情况下,引起线粒体损伤,导致凋亡因子通过开放的线粒体通透孔不受控制地释放到细胞质中。在此基础上,由于其疗效好、副作用小,在肿瘤学领域发挥着越来越重要的作用。然而,癌细胞自身对钙平衡的调节、肿瘤部位钙离子(Ca2+)不足以及钙离子进入肿瘤的效率低等因素限制了其疗效,导致治疗效果不理想。因此,研究人员构建了一种新型的 CAP/BSA@TCP-ZIF-8 纳米粒子药物载体系统,该系统可从外源提供 Ca2+,从而实现 pH 降解和药物释放的同时控制。体内和体外实验均证明,该纳米材料可激活 TRPV1 通道并提供外源 Ca2+,导致 Ca2+ 超载和细胞凋亡,从而达到抗肿瘤的效果。
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来源期刊
CiteScore
11.10
自引率
0.00%
发文量
133
审稿时长
42 days
期刊介绍: The mission of Nanomedicine: Nanotechnology, Biology, and Medicine (Nanomedicine: NBM) is to promote the emerging interdisciplinary field of nanomedicine. Nanomedicine: NBM is an international, peer-reviewed journal presenting novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the life and health sciences. Content includes basic, translational, and clinical research addressing diagnosis, treatment, monitoring, prediction, and prevention of diseases.
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