Single Method for Determination of Biocides Benzalkonium Chloride, Chloroxylenol and Chlorhexidine Gluconate in Cosmetics, Hygiene and Health Care Products by Using High Performance Liquid Chromatography.

IF 1.5 4区化学 Q4 BIOCHEMICAL RESEARCH METHODS

Journal of chromatographic science Pub Date : 2024-11-01 DOI:10.1093/chromsci/bmae039

Kumar Thangarathinam, Meenakshi Narayanan, Ashwin Kumar Ks, Banupriya Arjunan, Divya Bhavani Raja

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引用次数: 0

Abstract

Benzalkonium chloride (BKC), chloroxylenol (PCMX) and chlorhexidine gluconate (CHG) are widely recognized biocidal compounds that require precise control and monitoring in various applications, including cosmetics, hygiene, health and ophthalmic products. In this study, we present a straightforward and highly sensitive high-performance liquid chromatographic (HPLC) method for the detection of these substances. The HPLC method we developed allows for the detection of BKC at concentrations as low as 1.0 ppm, PCMX at 1.0 ppm and CHG at 2.0 ppm, all with a signal-to-noise (S/N) ratio exceeding 3.0. Additionally, the method enables quantification up to 2.0 ppm for BKC, 2.0 ppm for PCMX and 5 ppm for CHG, with an S/N ratio surpassing 10.0. This validated method serves as a versatile tool for the accurate quantification of BKC, PCMX and CHG in cosmetics, hygiene products, health products and ophthalmic products. Its applicability extends across a wide range of industries, ensuring the reliable assessment of these critical biocides.

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利用高效液相色谱法测定化妆品、卫生和保健产品中杀菌剂苯扎氯铵、氯甲酚和葡萄糖酸氯己定的单一方法。

苯扎氯铵 (BKC)、氯甲酚 (PCMX) 和葡萄糖酸氯己定 (CHG) 是公认的杀菌化合物，在化妆品、卫生用品、保健品和眼科产品等各种应用中都需要精确的控制和监测。在本研究中，我们提出了一种简单、高灵敏度的高效液相色谱 (HPLC) 方法来检测这些物质。我们开发的高效液相色谱法可检测浓度低至 1.0 ppm 的 BKC、1.0 ppm 的 PCMX 和 2.0 ppm 的 CHG，信噪比（S/N）均超过 3.0。此外，该方法还能对 BKC（2.0 ppm）、PCMX（2.0 ppm）和 CHG（5 ppm）进行定量，信噪比超过 10.0。这种经过验证的方法是准确定量化妆品、卫生用品、保健品和眼科产品中 BKC、PCMX 和 CHG 的多功能工具。它适用于广泛的行业，确保对这些关键杀菌剂进行可靠的评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of chromatographic science 化学-分析化学

CiteScore

2.90

自引率

7.70%

发文量

审稿时长

5.6 months

期刊介绍： The Journal of Chromatographic Science is devoted to the dissemination of information concerning all methods of chromatographic analysis. The standard manuscript is a description of recent original research that covers any or all phases of a specific separation problem, principle, or method. Manuscripts which have a high degree of novelty and fundamental significance to the field of separation science are particularly encouraged. It is expected the authors will clearly state in the Introduction how their method compares in some markedly new and improved way to previous published related methods. Analytical performance characteristics of new methods including sensitivity, tested limits of detection or quantification, accuracy, precision, and specificity should be provided. Manuscripts which describe a straightforward extension of a known analytical method or an application to a previously analyzed and/or uncomplicated sample matrix will not normally be reviewed favorably. Manuscripts in which mass spectrometry is the dominant analytical method and chromatography is of marked secondary importance may be declined.