Recent advances in post-column derivatization: Enhancing sensitivity and selectivity in liquid chromatography analysis

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry Pub Date : 2024-06-05 DOI:10.1016/j.trac.2024.117799

Endao Shi , Lihua Zuo , Huan Yao , Zhi Sun , Di Chen

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Abstract

The combination of post-column derivatization (PCD) and liquid chromatography (LC) has become a promising technique for enhancing detection sensitivity and selectivity, while simultaneously facilitating rapid and automated analysis. This paper presents a comprehensive review of PCD techniques spanning from 2013 to 2023, focusing on LC-UV-Vis/fluorescence spectrometry and LC-mass spectrometry detection methods. It encompasses an array of PCD methods, including chemical, photochemical, and electrochemical derivatization, as well as post-column complexation. This review delves deeply into key areas, exploring the underlying principles of derivatization, examining the current applications of classical PCD methods, and shedding light on emerging derivatization reactions. The review also provides remarks and insights into future directions, offering a perspective on the evolving landscape of the field. The overarching goal is to equip researchers with innovative ideas and strategies for PCD, thereby enhancing the practical application and utility of this technology in scientific research.

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柱后衍生化的最新进展：提高液相色谱分析的灵敏度和选择性

柱后衍生化（PCD）与液相色谱法（LC）的结合已成为提高检测灵敏度和选择性，同时促进快速和自动化分析的一项前景广阔的技术。本文全面回顾了从 2013 年到 2023 年的 PCD 技术，重点介绍了液相色谱-紫外-可见光/荧光光谱法和液相色谱-质谱检测方法。它涵盖了一系列 PCD 方法，包括化学、光化学和电化学衍生以及柱后络合。本综述深入探讨了关键领域，探讨了衍生化的基本原理，研究了经典 PCD 方法的当前应用，并揭示了新出现的衍生化反应。综述还对未来的发展方向提出了看法和见解，为该领域不断发展的前景提供了一个视角。其总体目标是让研究人员掌握 PCD 的创新理念和策略，从而提高这一技术在科学研究中的实际应用和效用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Analytical Chemistry 化学-分析化学

CiteScore

20.00

自引率

4.60%

发文量

257

审稿时长

3.4 months

期刊介绍： TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.