Junsong Guo , Hao Wang , Ying Li , Haijun Peng , Hui Xu , Xuefeng Ding , Xinyi Tian , Dongmei Wang , You Liao , Haiyang Jiang , Jing Wei , Hanfeng Yang , Houxiang Hu , Zhanjun Gu
{"title":"Fullerenol-mediated vascular regeneration and radioprotection: A strategy for tissue recovery post-radiation","authors":"Junsong Guo , Hao Wang , Ying Li , Haijun Peng , Hui Xu , Xuefeng Ding , Xinyi Tian , Dongmei Wang , You Liao , Haiyang Jiang , Jing Wei , Hanfeng Yang , Houxiang Hu , Zhanjun Gu","doi":"10.1016/j.nantod.2024.102339","DOIUrl":null,"url":null,"abstract":"<div><p>Radiation therapy is crucial in combating malignant tumors, yet its damage to the microvascular system can significantly impair patient recovery and prognosis. Although current radiation protection measures mitigate free radical damage to target organs, they fall short in safeguarding the surrounding microvasculature. This study pioneers the use of the matrigel plug angiogenesis model to investigate the application of the water-soluble fullerene derivative Fullerenol in microvascular radioprotection, aiming to effectively protect and repair the microvascular system during radiation therapy, thereby reducing its adverse effects on healthy tissues. Our findings demonstrate that Fullerenol not only efficiently scavenges free radicals, reducing radiation-induced damage, but also promotes endothelial cell proliferation, facilitating the repair of damaged microvasculature and surrounding tissues. Additionally, Fullerenol was found to inhibit Caspase-3 and activate the PI3K/AKT (Phosphoinositide 3-kinase/Protein kinase B) proliferation metabolic pathway and its downstream proteins, such as eNOS and VEGF (Endothelial nitric oxide synthase/Vascular endothelial growth factor), decreasing endothelial cell apoptosis and maintaining vascular proliferation and angiogenesis potential. This research provides a new option for microvascular radioprotection and offers fresh insights into the repair of tissues damaged by radiation therapy.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":null,"pages":null},"PeriodicalIF":13.2000,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano Today","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1748013224001944","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Radiation therapy is crucial in combating malignant tumors, yet its damage to the microvascular system can significantly impair patient recovery and prognosis. Although current radiation protection measures mitigate free radical damage to target organs, they fall short in safeguarding the surrounding microvasculature. This study pioneers the use of the matrigel plug angiogenesis model to investigate the application of the water-soluble fullerene derivative Fullerenol in microvascular radioprotection, aiming to effectively protect and repair the microvascular system during radiation therapy, thereby reducing its adverse effects on healthy tissues. Our findings demonstrate that Fullerenol not only efficiently scavenges free radicals, reducing radiation-induced damage, but also promotes endothelial cell proliferation, facilitating the repair of damaged microvasculature and surrounding tissues. Additionally, Fullerenol was found to inhibit Caspase-3 and activate the PI3K/AKT (Phosphoinositide 3-kinase/Protein kinase B) proliferation metabolic pathway and its downstream proteins, such as eNOS and VEGF (Endothelial nitric oxide synthase/Vascular endothelial growth factor), decreasing endothelial cell apoptosis and maintaining vascular proliferation and angiogenesis potential. This research provides a new option for microvascular radioprotection and offers fresh insights into the repair of tissues damaged by radiation therapy.
期刊介绍:
Nano Today is a journal dedicated to publishing influential and innovative work in the field of nanoscience and technology. It covers a wide range of subject areas including biomaterials, materials chemistry, materials science, chemistry, bioengineering, biochemistry, genetics and molecular biology, engineering, and nanotechnology. The journal considers articles that inform readers about the latest research, breakthroughs, and topical issues in these fields. It provides comprehensive coverage through a mixture of peer-reviewed articles, research news, and information on key developments. Nano Today is abstracted and indexed in Science Citation Index, Ei Compendex, Embase, Scopus, and INSPEC.