The role of mitochondrial genes in ischemia-reperfusion injury: A systematic review of experimental studies

IF 3.9 3区生物学 Q2 CELL BIOLOGY

Mitochondrion Pub Date : 2024-06-06 DOI:10.1016/j.mito.2024.101908

Zeyu Chen , Daniel Rayner , Robert Morton , Laura Banfield , Guillaume Paré , Michael Chong

引用次数: 0

Abstract

Mitochondrial dysfunction contributes to pathological conditions like ischemia–reperfusion (IR) injury. To address the lack of effective therapeutic interventions for IR injury and potential knowledge gaps in the current literature, we systematically reviewed 3800 experimental studies across 5 databases and identified 20 mitochondrial genes impacting IR injury in various organs. Notably, CyPD, Nrf2, and GPX4 are well-studied genes consistently influencing IR injury outcomes. Emerging genes like ALDH2, BNIP3, and OPA1 are supported by human genetic evidence, thereby warranting further investigation. Findings of this review can inform future research directions and inspire therapeutic advancements.

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线粒体基因在缺血再灌注损伤中的作用：实验研究的系统回顾。

线粒体功能障碍会导致缺血再灌注（IR）损伤等病理状况。为了解决线粒体损伤缺乏有效治疗干预的问题以及现有文献中潜在的知识空白，我们系统地回顾了 5 个数据库中的 3800 项实验研究，并确定了 20 个影响不同器官线粒体损伤的线粒体基因。值得注意的是，CyPD、Nrf2 和 GPX4 是研究较多的基因，一直影响着红外损伤的结果。ALDH2、BNIP3 和 OPA1 等新出现的基因得到了人类遗传学证据的支持，因此值得进一步研究。本综述的研究结果可为未来的研究方向提供参考，并激励治疗方法的进步。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mitochondrion 生物-细胞生物学

CiteScore

9.40

自引率

4.50%

发文量

审稿时长

13.6 weeks

期刊介绍： Mitochondrion is a definitive, high profile, peer-reviewed international research journal. The scope of Mitochondrion is broad, reporting on basic science of mitochondria from all organisms and from basic research to pathology and clinical aspects of mitochondrial diseases. The journal welcomes original contributions from investigators working in diverse sub-disciplines such as evolution, biophysics, biochemistry, molecular and cell biology, genetics, pharmacology, toxicology, forensic science, programmed cell death, aging, cancer and clinical features of mitochondrial diseases.