Zicheng Zhang , Wenfeng Wu , Meng Li , Longbo Du , Jiantao Li , Xin Yin , Wei Zhang
{"title":"Mesenchymal stem cell–derived extracellular vesicles: A novel nanoimmunoregulatory tool in musculoskeletal diseases","authors":"Zicheng Zhang , Wenfeng Wu , Meng Li , Longbo Du , Jiantao Li , Xin Yin , Wei Zhang","doi":"10.1016/j.nantod.2024.102343","DOIUrl":null,"url":null,"abstract":"<div><p>The musculoskeletal system involves various cell types that participate in maintaining bone homeostasis, which is crucial for balancing osteogenesis and osteoclastogenesis. Imbalances in bone homeostasis can lead to numerous musculoskeletal disorders, including osteoarthritis (OA) and osteoporosis (OP). In recent years, there has been growing interest in osteoimmunity due to its significant regulatory impact on bone homeostasis. Various cell types, including macrophages, T cells, and B cells, participate in osteoimmunology and regulate bone homeostasis. Currently, extracellular vesicles (EVs) play crucial roles in cell-to-cell communication. In particular, mesenchymal stem cell (MSC)-derived EVs have been reported as potential immunoregulators in certain immune-related diseases. This comprehensive review aims to present recent advancements in the understanding of the immunoregulatory effects of MSC-derived EVs in musculoskeletal diseases. In addition, we discuss the immunoregulatory effects of MSC-EVs on programed cell death in osteoblasts, osteoclasts, and chondrocytes, and the effect of this modulation on bone homeostasis. Moreover, we provide insights into the potential applications of MSC-EVs in the management of prevalent musculoskeletal disorders, including OP, OA, and bone fractures. In conclusion, this review emphasizes current advancements in research and future directions in MSC-EV-based therapies for musculoskeletal disorders.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":null,"pages":null},"PeriodicalIF":13.2000,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano Today","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1748013224001981","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
The musculoskeletal system involves various cell types that participate in maintaining bone homeostasis, which is crucial for balancing osteogenesis and osteoclastogenesis. Imbalances in bone homeostasis can lead to numerous musculoskeletal disorders, including osteoarthritis (OA) and osteoporosis (OP). In recent years, there has been growing interest in osteoimmunity due to its significant regulatory impact on bone homeostasis. Various cell types, including macrophages, T cells, and B cells, participate in osteoimmunology and regulate bone homeostasis. Currently, extracellular vesicles (EVs) play crucial roles in cell-to-cell communication. In particular, mesenchymal stem cell (MSC)-derived EVs have been reported as potential immunoregulators in certain immune-related diseases. This comprehensive review aims to present recent advancements in the understanding of the immunoregulatory effects of MSC-derived EVs in musculoskeletal diseases. In addition, we discuss the immunoregulatory effects of MSC-EVs on programed cell death in osteoblasts, osteoclasts, and chondrocytes, and the effect of this modulation on bone homeostasis. Moreover, we provide insights into the potential applications of MSC-EVs in the management of prevalent musculoskeletal disorders, including OP, OA, and bone fractures. In conclusion, this review emphasizes current advancements in research and future directions in MSC-EV-based therapies for musculoskeletal disorders.
期刊介绍:
Nano Today is a journal dedicated to publishing influential and innovative work in the field of nanoscience and technology. It covers a wide range of subject areas including biomaterials, materials chemistry, materials science, chemistry, bioengineering, biochemistry, genetics and molecular biology, engineering, and nanotechnology. The journal considers articles that inform readers about the latest research, breakthroughs, and topical issues in these fields. It provides comprehensive coverage through a mixture of peer-reviewed articles, research news, and information on key developments. Nano Today is abstracted and indexed in Science Citation Index, Ei Compendex, Embase, Scopus, and INSPEC.