Serum amyloid P component: Structure, biological activity, and application in diagnosis and treatment of immune-associated diseases

IF 3.2 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular immunology Pub Date : 2024-06-07 DOI:10.1016/j.molimm.2024.05.009

Haixia Wang , Yadan Nie , Zuoli Sun , Yi He , Jian Yang

{"title":"Serum amyloid P component: Structure, biological activity, and application in diagnosis and treatment of immune-associated diseases","authors":"Haixia Wang , Yadan Nie , Zuoli Sun , Yi He , Jian Yang","doi":"10.1016/j.molimm.2024.05.009","DOIUrl":null,"url":null,"abstract":"<div><p>Serum amyloid P component (SAP) is a member the innate immune humoral arm and participated in various processes, including the innate immune responses, tissue remodeling, and the pathogenesis of inflammatory diseases. Remarkably, SAP is a highly versatile immunomodulatory factor that can serve as a drug target for treating amyloid diseases and reduce inflammation, fibrosis degree, and respiratory disease. In this review, we focus on the biological activities of SAP and its application in different systemic immune-associated diseases. First, we reviewed the regulatory effects of SAP on innate immune cells and possible mechanisms. Second, we emphasized SAP as a diagnostic marker and therapeutic target for immune-associated diseases, including the neuropsychiatric disorders. Third, we presented several recommendations for regulating SAP in immune cell function and potential areas for future research. Some authorities consider SAP to be a pattern recognition molecule that plays multiple roles in the innate immune system and inflammation. Developing therapeutics that target SAP or its associated signaling pathways may be a promising strategy for treating immune-associated diseases.</p></div>","PeriodicalId":18938,"journal":{"name":"Molecular immunology","volume":null,"pages":null},"PeriodicalIF":3.2000,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0161589024001007/pdfft?md5=8ca44b9fd52dfebe0d3d3b79035f26f8&pid=1-s2.0-S0161589024001007-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular immunology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0161589024001007","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Serum amyloid P component (SAP) is a member the innate immune humoral arm and participated in various processes, including the innate immune responses, tissue remodeling, and the pathogenesis of inflammatory diseases. Remarkably, SAP is a highly versatile immunomodulatory factor that can serve as a drug target for treating amyloid diseases and reduce inflammation, fibrosis degree, and respiratory disease. In this review, we focus on the biological activities of SAP and its application in different systemic immune-associated diseases. First, we reviewed the regulatory effects of SAP on innate immune cells and possible mechanisms. Second, we emphasized SAP as a diagnostic marker and therapeutic target for immune-associated diseases, including the neuropsychiatric disorders. Third, we presented several recommendations for regulating SAP in immune cell function and potential areas for future research. Some authorities consider SAP to be a pattern recognition molecule that plays multiple roles in the innate immune system and inflammation. Developing therapeutics that target SAP or its associated signaling pathways may be a promising strategy for treating immune-associated diseases.

查看原文本刊更多论文

血清淀粉样蛋白 P 成分：结构、生物活性以及在诊断和治疗免疫相关疾病中的应用

血清淀粉样蛋白 P 成分（SAP）是先天性免疫体液臂的成员之一，参与先天性免疫反应、组织重塑和炎症性疾病发病机制等多个过程。值得注意的是，SAP 是一种用途广泛的免疫调节因子，可作为治疗淀粉样蛋白疾病的药物靶点，并能减轻炎症、纤维化程度和呼吸系统疾病。在这篇综述中，我们重点探讨了 SAP 的生物活性及其在不同系统性免疫相关疾病中的应用。首先，我们回顾了 SAP 对先天性免疫细胞的调节作用及其可能的机制。其次，我们强调了 SAP 作为免疫相关疾病（包括神经精神疾病）的诊断标志物和治疗靶点的作用。第三，我们就如何调节 SAP 在免疫细胞功能中的作用以及未来研究的潜在领域提出了一些建议。一些权威人士认为，SAP 是一种模式识别分子，在先天性免疫系统和炎症中发挥着多重作用。开发针对SAP或其相关信号通路的疗法可能是治疗免疫相关疾病的一种有前途的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Molecular immunology 医学-免疫学

CiteScore

6.90

自引率

2.80%

发文量

324

审稿时长

50 days

期刊介绍： Molecular Immunology publishes original articles, reviews and commentaries on all areas of immunology, with a particular focus on description of cellular, biochemical or genetic mechanisms underlying immunological phenomena. Studies on all model organisms, from invertebrates to humans, are suitable. Examples include, but are not restricted to: Infection, autoimmunity, transplantation, immunodeficiencies, inflammation and tumor immunology Mechanisms of induction, regulation and termination of innate and adaptive immunity Intercellular communication, cooperation and regulation Intracellular mechanisms of immunity (endocytosis, protein trafficking, pathogen recognition, antigen presentation, etc) Mechanisms of action of the cells and molecules of the immune system Structural analysis Development of the immune system Comparative immunology and evolution of the immune system "Omics" studies and bioinformatics Vaccines, biotechnology and therapeutic manipulation of the immune system (therapeutic antibodies, cytokines, cellular therapies, etc) Technical developments.