Extracellular vesicles as modifiers of epigenomic profiles.

IF 13.6 2区 生物学 Q1 GENETICS & HEREDITY
Trends in Genetics Pub Date : 2024-09-01 Epub Date: 2024-06-05 DOI:10.1016/j.tig.2024.05.005
Haifeng Zhou, Sheng Hu, Wei Yan
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引用次数: 0

Abstract

Extracellular vesicles (EVs), emerging as novel mediators between intercellular communication, encapsulate distinct bioactive cargoes to modulate multiple biological events, such as epigenetic remodeling. In essence, EVs and epigenomic profiles are tightly linked and reciprocally regulated. Epigenetic factors, including histone and DNA modifications, noncoding RNAs, and protein post-translational modifications (PTMs) dynamically regulate EV biogenesis to contribute to EV heterogeneity. Alternatively, EVs actively modify DNA, RNA, and histone profiles in recipient cells by delivering RNA and protein cargoes for downstream epigenetic enzyme regulation. Moreover, EVs display great potential as diagnostic markers and drug-delivery vehicles for therapeutic applications. The combination of parental cell epigenomic modification with single EV characterization would be a promising strategy for EV engineering to enhance the epidrug loading efficacy and accuracy.

细胞外囊泡是表观基因组图谱的调节剂。
细胞外囊泡(EVs)作为细胞间通信的新型媒介,包裹着不同的生物活性货物,可调节多种生物事件,如表观遗传重塑。从本质上讲,EV 和表观基因组图谱是紧密联系和相互调控的。表观遗传因素,包括组蛋白和DNA修饰、非编码RNA和蛋白质翻译后修饰(PTM),动态调节EV的生物发生,从而导致EV的异质性。此外,EVs 还能主动改变受体细胞中的 DNA、RNA 和组蛋白谱,为下游表观遗传酶调控提供 RNA 和蛋白质载体。此外,EVs 作为诊断标志物和药物输送载体,在治疗应用方面显示出巨大潜力。将亲代细胞表观基因组学修饰与单个EV特征描述相结合,将是EV工程学提高表观药物负载功效和准确性的一种有前途的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Trends in Genetics
Trends in Genetics 生物-遗传学
CiteScore
20.90
自引率
0.90%
发文量
160
审稿时长
6-12 weeks
期刊介绍: Launched in 1985, Trends in Genetics swiftly established itself as a "must-read" for geneticists, offering concise, accessible articles covering a spectrum of topics from developmental biology to evolution. This reputation endures, making TiG a cherished resource in the genetic research community. While evolving with the field, the journal now embraces new areas like genomics, epigenetics, and computational genetics, alongside its continued coverage of traditional subjects such as transcriptional regulation, population genetics, and chromosome biology. Despite expanding its scope, the core objective of TiG remains steadfast: to furnish researchers and students with high-quality, innovative reviews, commentaries, and discussions, fostering an appreciation for advances in genetic research. Each issue of TiG presents lively and up-to-date Reviews and Opinions, alongside shorter articles like Science & Society and Spotlight pieces. Invited from leading researchers, Reviews objectively chronicle recent developments, Opinions provide a forum for debate and hypothesis, and shorter articles explore the intersection of genetics with science and policy, as well as emerging ideas in the field. All articles undergo rigorous peer-review.
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