Phylogenetic analysis and molecular genetic characteristics of West Nile virus lineage 2 isolates circulating in the Russian Federation.

IF 1.9 4区医学 Q3 GENETICS & HEREDITY

Virus Genes Pub Date : 2024-08-01 Epub Date: 2024-06-07 DOI:10.1007/s11262-024-02079-2

A S Antonov, I M Shpak, D V Ustinov, M P Izhberdeeva, A N Guseva, A Y Galkina, N V Borodai, S K Udovichenko, A V Toporkov

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Abstract

Since its initial detection in Africa, the West Nile virus has disseminated widely across all continents, becoming endemic in numerous countries, including the Russian Federation. A substantial expansion of the West Nile virus range was observed in the European part of the Russian territory in 1999. In light of this epidemiological trend, research endeavours focusing on monitoring West Nile virus circulation activity in endemic regions of the country have gained paramount significance. A substantial dataset has been accrued from 2007 onwards regarding genomic variability and dissemination dynamics across the country throughout the entire monitoring period for the West Nile fever pathogen. The objective of this study was to characterise West Nile virus isolates that have been circulating in the Russian Federation and identify their molecular and genetic characteristics. A phylogenetic analysis of 55 complete genome sequences revealed that the West Nile virus population within the Russian Federation is genetically heterogeneous and is represented by four major clades. One of these clades is currently exhibiting extensive spread into new regions of the country.

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俄罗斯联邦流行的西尼罗河病毒 2 系分离株的系统发育分析和分子遗传特征。

自最初在非洲发现西尼罗河病毒以来，该病毒已在各大洲广泛传播，成为包括俄罗斯联邦在内的许多国家的地方病。1999 年，西尼罗河病毒的传播范围在俄罗斯领土的欧洲部分大幅扩大。鉴于这种流行病学趋势，重点监测西尼罗河病毒在俄罗斯流行地区的循环活动的研究工作变得至关重要。自 2007 年起，在整个西尼罗河热病原体监测期间，已积累了大量关于全国基因组变异性和传播动态的数据集。本研究的目的是描述在俄罗斯联邦流行的西尼罗河病毒分离物的特征，并确定其分子和遗传特征。对 55 个完整基因组序列进行的系统进化分析表明，俄罗斯联邦境内的西尼罗河病毒种群具有遗传异质性，由四个主要支系代表。其中一个支系目前正在向该国新的地区广泛传播。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Virus Genes 医学-病毒学

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Viruses are convenient models for the elucidation of life processes. The study of viruses is again on the cutting edge of biological sciences: systems biology, genomics, proteomics, metagenomics, using the newest most powerful tools. Huge amounts of new details on virus interactions with the cell, other pathogens and the hosts – animal (including human), insect, fungal, plant, bacterial, and archaeal - and their role in infection and disease are forthcoming in perplexing details requiring analysis and comments. Virus Genes is dedicated to the publication of studies on the structure and function of viruses and their genes, the molecular and systems interactions with the host and all applications derived thereof, providing a forum for the analysis of data and discussion of its implications, and the development of new hypotheses.