The Effect of Palmitoylethanolamide (PEA) on Skeletal Muscle Hypertrophy, Strength, and Power in Response to Resistance Training in Healthy Active Adults: A Double-Blind Randomized Control Trial.

IF 4.1 2区 医学 Q1 SPORT SCIENCES
Zoya Huschtscha, Jessica Silver, Michael Gerhardy, Charles S Urwin, Nathan Kenney, Viet Hung Le, Jackson J Fyfe, Simon A Feros, Andrew C Betik, Christopher S Shaw, Luana C Main, Gavin Abbott, Sze-Yen Tan, Anthony May, Craig M Smith, Vicky Kuriel, Jackson Barnard, D Lee Hamilton
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引用次数: 0

Abstract

Background: Palmitoylethanolamide (PEA) has analgesic/anti-inflammatory properties that may be a suitable alternative to over-the-counter (OTC) non-steroidal analgesics/anti-inflammatories. While OTC pain medications can impair strength training adaptations, the mechanism of action of PEA is distinct from these and it may not negatively affect skeletal muscle adaptations to strength training.

Methods: The primary aim of this study was to investigate the effects of daily PEA supplementation (350 mg Levagen + equivalent to 300 mg PEA) combined with 8-weeks of resistance training on lean body mass with secondary aims addressing strength, power, sleep, and wellbeing compared to placebo (PLA) in young, healthy, active adults. In a randomized, controlled, double-blinded trial, 52 untrained, recreationally active participants aged 18-35 y were allocated to either the PEA or PLA groups. Participants consumed either 2 × 175 mg Levagen + PEA or identically matched maltodextrin capsules during an 8-week period of whole-body resistance training. This trial assessed the pre- to post- changes in total and regional lean body mass, muscular strength (1-RM bench, isometric mid-thigh pull), muscular power [countermovement jump (CMJ), bench throw], pain associated with exercise training, sleep, and wellbeing compared with the PEA or PLA condition.

Results: 48 Participants were included in the final intention to treat (ITT) analysis and we also conducted per protocol (PP) analysis (n = 42). There were no significant between-group differences for total or regional lean muscle mass post-intervention. There was a significantly higher jump height (CMJ) at week 10 in the PEA group compared to the PLA (Adjusted mean difference [95% CI] p-value; ITT: - 2.94 cm [- 5.15, - 0.74] p = 0.010; PP: - 2.93 cm [- 5.31, - 0.55] p = 0.017). The PLA group had higher 1-RM bench press post-intervention compared with the PEA group (ITT: 2.24 kg [0.12, 4.37] p = 0.039; PP: 2.73 kg [0.40, 5.06] p = 0.023). No significant treatment effects were noted for any of the other outcomes.

Conclusion: PEA supplementation, when combined with 8 weeks of strength training, did not impair lean mass gains and it resulted in significantly higher dynamic lower-body power when compared with the PLA condition.

Trial registration: Australian New Zealand Clinical Trials Registry (ANZCTR: ACTRN12621001726842p).

棕榈酰乙醇酰胺 (PEA) 对健康活跃成人阻力训练下骨骼肌肥大、力量和功率的影响:双盲随机对照试验》。
背景:棕榈酰乙醇酰胺(Palmitoylethanolamide,PEA)具有镇痛/消炎特性,可作为非处方(OTC)非甾体镇痛/消炎药的合适替代品。虽然非处方止痛药会影响力量训练的适应性,但 PEA 的作用机制与之不同,可能不会对骨骼肌对力量训练的适应性产生负面影响:本研究的主要目的是调查每日补充 PEA(350 毫克利伐根 + 相当于 300 毫克 PEA)并进行为期 8 周的阻力训练对瘦体重的影响,其次是与安慰剂(PLA)相比,对力量、力量、睡眠和健康的影响。在一项随机对照双盲试验中,52 名年龄在 18-35 岁之间、未经训练的娱乐活动参与者被分配到 PEA 组或 PLA 组。在为期 8 周的全身阻力训练期间,参与者服用 2 × 175 毫克利伐根 + PEA 或相同配比的麦芽糊精胶囊。该试验评估了与 PEA 或 PLA 条件相比,总瘦身质量和区域瘦身质量、肌肉力量(1-RM 卧推,等长大腿中部拉力)、肌肉力量[反向移动跳跃(CMJ),卧推]、与运动训练相关的疼痛、睡眠和幸福感的前后变化:48名参与者参与了最终的意向治疗(ITT)分析,我们还进行了按方案(PP)分析(n = 42)。干预后,总肌肉量或区域瘦肌肉量在组间无明显差异。与 PLA 相比,PEA 组在第 10 周的跳跃高度(CMJ)明显更高(调整后的平均差异 [95% CI] p 值;ITT:- 2.94 厘米 [- 5.15, - 0.74] p = 0.010;PP:- 2.93 厘米 [- 5.31, - 0.55] p = 0.017)。与 PEA 组相比,PLA 组在干预后的 1-RM 卧推次数更高(ITT:2.24 kg [0.12, 4.37] p = 0.039;PP:2.73 kg [0.40, 5.06] p = 0.023)。结论:补充 PEA 并与其他疗法结合使用时,不会产生明显的治疗效果:结论:补充 PEA 并进行为期 8 周的力量训练不会影响瘦体重的增加,与 PLA 条件相比,补充 PEA 可显著提高下半身动态力量:试验注册:澳大利亚-新西兰临床试验注册中心(ANZCTR:ACTRN12621001726842p)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Sports Medicine - Open
Sports Medicine - Open SPORT SCIENCES-
CiteScore
7.00
自引率
4.30%
发文量
142
审稿时长
13 weeks
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