Effect of oral multispecies probiotic on wound healing, periodontitis and quality of life on patients with diabetes.

IF 1.5 4区医学 Q3 DERMATOLOGY

Journal of wound care Pub Date : 2024-06-02 DOI:10.12968/jowc.2023.0302

Ewa Klara Stuermer, Corinna Bang, Anna Giessler, Ralf Smeets, Toni Maria Janke, Filip David Seki, Eike Sebastian Debus, Andre Franke, Matthias Augustin

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引用次数: 0

Abstract

Objective: Hard-to-heal (chronic) wounds are common in patients with diabetes and are associated with a decrease in quality of life (QoL). Pathogenic bacteria often colonise hard-to-heal wounds and hinder the healing process which poses a high risk for (systemic) infections. In this study, we aim to prove that probiotics are capable of displacing human pathogenic bacteria, ameliorating inflammation and positively influencing the microenvironment/microbiome of skin and mucosa.

Method: In this pilot study, patients with diabetes and hard-to-heal wounds with a duration of 2-120 months received an oral multispecies probiotic daily for six months. Changes in oral, stool and wound microbiome were investigated, and the effects of the probiotic intervention on wound healing, periodontitis and wound-specific quality of life (Wound-QOL-17) were analysed throughout the course of this clinical study.

Results: In total, seven of the 20 patients included were unable to complete the study. After six months of oral probiotic intake supplementation in five out of the remaining 13 patients, the wounds had healed completely. Most patients reported an improvement in wound-specific QoL, with particular positive effects on pain and mobility. Microbiome analysis revealed a reduction in Staphylococcus aureus and Pseudomonas aeruginosa, and Staphylococcus epidermis in healed wounds.

Conclusion: This findings of this study provide evidence for the beneficial effects of the oral application of a multispecies probiotic over six months in patients with diabetes and hard-to-heal wounds on wound closure, wound microbial pattern, QoL, and on dental health. A randomised, placebo-controlled, double-blinded clinical trial is required to verify the results.

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口服多菌种益生菌对糖尿病患者伤口愈合、牙周炎和生活质量的影响。

目的：难愈合（慢性）伤口在糖尿病患者中很常见，与生活质量（QoL）下降有关。致病菌通常会在难以愈合的伤口上定植，阻碍伤口愈合，从而造成（全身性）感染的高风险。在这项研究中，我们旨在证明益生菌能够取代人类致病菌，改善炎症，并对皮肤和粘膜的微环境/微生物组产生积极影响：在这项试验性研究中，病程为 2-120 个月的糖尿病患者和伤口难以愈合的患者每天口服多菌种益生菌，为期 6 个月。研究人员调查了口腔、粪便和伤口微生物组的变化，并在整个临床研究过程中分析了益生菌干预对伤口愈合、牙周炎和伤口生活质量（Wound-QOL-17）的影响：结果：20 名患者中共有 7 人无法完成研究。剩下的 13 名患者中，有 5 人在口服益生菌 6 个月后伤口完全愈合。大多数患者都表示伤口的质量生活得到了改善，尤其是对疼痛和活动能力产生了积极影响。微生物组分析显示，愈合伤口中的金黄色葡萄球菌、铜绿假单胞菌和表皮葡萄球菌有所减少：本研究结果证明，糖尿病患者在伤口难以愈合的情况下口服多菌种益生菌 6 个月，对伤口愈合、伤口微生物模式、生活质量和牙齿健康都有好处。需要进行随机、安慰剂对照、双盲临床试验来验证结果。

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来源期刊

Journal of wound care DERMATOLOGY-

CiteScore

2.90

自引率

10.50%

发文量

215

期刊介绍： Journal of Wound Care (JWC) is the definitive wound-care journal and the leading source of up-to-date research and clinical information on everything related to tissue viability. The journal was first launched in 1992 and aimed at catering to the needs of the multidisciplinary team. Published monthly, the journal’s international audience includes nurses, doctors and researchers specialising in wound management and tissue viability, as well as generalists wishing to enhance their practice. In addition to cutting edge and state-of-the-art research and practice articles, JWC also covers topics related to wound-care management, education and novel therapies, as well as JWC cases supplements, a supplement dedicated solely to case reports and case series in wound care. All articles are rigorously peer-reviewed by a panel of international experts, comprised of clinicians, nurses and researchers. Specifically, JWC publishes: High quality evidence on all aspects of wound care, including leg ulcers, pressure ulcers, the diabetic foot, burns, surgical wounds, wound infection and more The latest developments and innovations in wound care through both preclinical and preliminary clinical trials of potential new treatments worldwide In-depth prospective studies of new treatment applications, as well as high-level research evidence on existing treatments Clinical case studies providing information on how to deal with complex wounds Comprehensive literature reviews on current concepts and practice, including cost-effectiveness Updates on the activities of wound care societies around the world.