Comparing withdrawal- and anxiety-like behaviors following oral and subcutaneous oxycodone administration in C57BL/6 mice.

IF 1.6 4区 心理学 Q3 BEHAVIORAL SCIENCES
Behavioural Pharmacology Pub Date : 2024-08-01 Epub Date: 2024-06-03 DOI:10.1097/FBP.0000000000000780
Suzannah S De Almeida, Caryssa R Drinkuth, Gregory C Sartor
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引用次数: 0

Abstract

Excessive prescribing and misuse of prescription opioids, such as oxycodone, significantly contributed to the current opioid crisis. Although oxycodone is typically consumed orally by humans, parenteral routes of administration have primarily been used in preclinical models of oxycodone dependence. To address this issue, more recent studies have used oral self-administration procedures to study oxycodone seeking and withdrawal in rodents. Behavioral differences, however, following oral oxycodone intake versus parenteral oxycodone administration remain unclear. Thus, the goal of the current studies was to compare anxiety- and withdrawal-like behaviors using established opioid dependence models of either home cage oral intake of oxycodone (0.5 mg/ml) or repeated subcutaneous (s.c.) injections of oxycodone (10 mg/kg) in male and female mice. Here, mice received 10 days of oral or s.c. oxycodone administration, and following 72 h of forced abstinence, anxiety- and withdrawal-like behaviors were measured using elevated zero maze, open field, and naloxone-induced precipitated withdrawal procedures. Global withdrawal scores were increased to a similar degree following oral and s.c. oxycodone use, while both routes of oxycodone administration had minimal effects on anxiety-like behaviors. When examining individual withdrawal-like behaviors, mice receiving s.c. oxycodone exhibited more paw tremors and jumps during naloxone-induced precipitated withdrawal compared with oral oxycodone mice. These results indicate that both models of oxycodone administration are sufficient to elevate global withdrawal scores, but, when compared with oral consumption, s.c. oxycodone injections yielded more pronounced effects on some withdrawal-like behaviors.

比较 C57BL/6 小鼠口服和皮下注射羟考酮后的戒断和焦虑行为。
处方类阿片(如羟考酮)的过度处方和滥用在很大程度上导致了当前的阿片类药物危机。虽然人类通常口服羟考酮,但肠道外给药途径主要用于羟考酮依赖性的临床前模型。为了解决这个问题,最近的研究使用口服自我给药程序来研究啮齿类动物对羟考酮的寻求和戒断。然而,口服羟考酮与肠外注射羟考酮后的行为差异仍不清楚。因此,本研究的目的是利用已建立的阿片类药物依赖模型,比较雌雄小鼠在家庭笼中口服羟考酮(0.5 毫克/毫升)或反复皮下注射羟考酮(10 毫克/千克)后的焦虑和戒断行为。在这里,小鼠接受了为期 10 天的口服或皮下注射羟考酮治疗,在强迫戒断 72 小时后,使用高架零迷宫、空旷场地和纳洛酮诱导的沉淀戒断程序测量了焦虑和戒断样行为。口服和静脉注射羟考酮后,总体戒断评分的增加程度相似,而两种羟考酮给药途径对焦虑样行为的影响都很小。与口服羟考酮的小鼠相比,静脉注射羟考酮的小鼠在纳洛酮诱导的沉淀性戒断过程中表现出更多的爪颤和跳跃。这些结果表明,两种羟考酮给药模式都足以提高总体戒断评分,但与口服相比,静脉注射羟考酮对某些戒断样行为的影响更为明显。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Behavioural Pharmacology
Behavioural Pharmacology 医学-行为科学
CiteScore
3.40
自引率
0.00%
发文量
84
审稿时长
6-12 weeks
期刊介绍: Behavioural Pharmacology accepts original full and short research reports in diverse areas ranging from ethopharmacology to the pharmacology of schedule-controlled operant behaviour, provided that their primary focus is behavioural. Suitable topics include drug, chemical and hormonal effects on behaviour, the neurochemical mechanisms under-lying behaviour, and behavioural methods for the study of drug action. Both animal and human studies are welcome; however, studies reporting neurochemical data should have a predominantly behavioural focus, and human studies should not consist exclusively of clinical trials or case reports. Preference is given to studies that demonstrate and develop the potential of behavioural methods, and to papers reporting findings of direct relevance to clinical problems. Papers making a significant theoretical contribution are particularly welcome and, where possible and merited, space is made available for authors to explore fully the theoretical implications of their findings. Reviews of an area of the literature or at an appropriate stage in the development of an author’s own work are welcome. Commentaries in areas of current interest are also considered for publication, as are Reviews and Commentaries in areas outside behavioural pharmacology, but of importance and interest to behavioural pharmacologists. Behavioural Pharmacology publishes frequent Special Issues on current hot topics. The editors welcome correspondence about whether a paper in preparation might be suitable for inclusion in a Special Issue.
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