The lipid side of unfolded protein response

IF 3.9 2区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Wojciech Białek , Anita Hryniewicz-Jankowska , Paulina Czechowicz , Jakub Sławski , James F. Collawn , Aleksander Czogalla , Rafał Bartoszewski
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引用次数: 0

Abstract

Although our current knowledge of the molecular crosstalk between the ER stress, the unfolded protein response (UPR), and lipid homeostasis remains limited, there is increasing evidence that dysregulation of either protein or lipid homeostasis profoundly affects the other. Most research regarding UPR signaling in human diseases has focused on the causes and consequences of disrupted protein folding. The UPR itself consists of very complex pathways that function to not only maintain protein homeostasis, but just as importantly, modulate lipid biogenesis to allow the ER to adjust and promote cell survival. Lipid dysregulation is known to activate many aspects of the UPR, but the complexity of this crosstalk remains a major research barrier. ER lipid disequilibrium and lipotoxicity are known to be important contributors to numerous human pathologies, including insulin resistance, liver disease, cardiovascular diseases, neurodegenerative diseases, and cancer. Despite their medical significance and continuous research, however, the molecular mechanisms that modulate lipid synthesis during ER stress conditions, and their impact on cell fate decisions, remain poorly understood. Here we summarize the current view on crosstalk and connections between altered lipid metabolism, ER stress, and the UPR.

折叠蛋白反应的脂质方面
尽管我们目前对ER应激、未折叠蛋白质反应(UPR)和脂质稳态之间的分子相互关系的了解仍然有限,但越来越多的证据表明,蛋白质或脂质稳态失调会对两者产生深远的影响。有关人类疾病中 UPR 信号传导的大多数研究都集中在蛋白质折叠紊乱的原因和后果上。UPR 本身由非常复杂的通路组成,其功能不仅是维持蛋白质的平衡,同样重要的是调节脂质的生物生成,使 ER 能够进行调整并促进细胞存活。众所周知,脂质失调会激活 UPR 的许多方面,但这种相互影响的复杂性仍然是研究的一大障碍。众所周知,ER 脂质失衡和脂毒性是导致胰岛素抵抗、肝病、心血管疾病、神经退行性疾病和癌症等多种人类病症的重要因素。尽管它们具有重要的医学意义,研究也在不断深入,但人们对ER应激状态下调节脂质合成的分子机制及其对细胞命运决定的影响仍然知之甚少。在此,我们总结了目前关于脂质代谢改变、ER 应激和 UPR 之间相互影响和联系的观点。
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来源期刊
CiteScore
11.00
自引率
2.10%
发文量
109
审稿时长
53 days
期刊介绍: BBA Molecular and Cell Biology of Lipids publishes papers on original research dealing with novel aspects of molecular genetics related to the lipidome, the biosynthesis of lipids, the role of lipids in cells and whole organisms, the regulation of lipid metabolism and function, and lipidomics in all organisms. Manuscripts should significantly advance the understanding of the molecular mechanisms underlying biological processes in which lipids are involved. Papers detailing novel methodology must report significant biochemical, molecular, or functional insight in the area of lipids.
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