Coumarin-based fluorescent probes for the detection of ions, biomolecules and biochemical species responsible for diseases

IF 4.1 3区工程技术 Q2 CHEMISTRY, APPLIED

Dyes and Pigments Pub Date : 2024-06-03 DOI:10.1016/j.dyepig.2024.112257

Samarpita Das, Harish K. Indurthi, Pallavi Saha, Deepak K. Sharma

引用次数: 0

Abstract

Research on fluorescent probes has come a long way in the last few years. Among a palette of small molecule fluorescent probes, coumarin-based probes have gained a lot of attention in the last few decades. Considerable advancements have been made in the development and application of coumarin fluorescent probes. These are becoming more widely used in biochemistry, environmental protection, and disease detection due to their substantial Stokes shift, high quantum yield, excellent biocompatibility, and cell-membrane permeability. Novel coumarin fluorescent probes can be designed by altering the current substituents on the coumarin scaffold and can be applied to detection and identification of several analytes by conjugating it with a variety of recognition units. To date, several reviews on coumarin-based small molecular probes have been reported. The current review focuses on the recent advances of these coumarin probes since 2018.

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用于检测导致疾病的离子、生物大分子和生化物种的香豆素基荧光探针

荧光探针研究在过去几年中取得了长足的进步。在众多小分子荧光探针中，香豆素类探针在过去几十年里受到了广泛关注。香豆素荧光探针的开发和应用取得了长足的进步。由于香豆素荧光探针具有可观的斯托克斯位移、高量子产率、良好的生物相容性和细胞膜渗透性，因此在生物化学、环境保护和疾病检测领域的应用越来越广泛。通过改变香豆素支架上的现有取代基，可以设计出新型香豆素荧光探针，并通过将其与多种识别单元共轭，应用于多种分析物的检测和鉴定。迄今为止，已有多篇关于香豆素基小分子探针的综述报道。本综述重点介绍了 2018 年以来这些香豆素探针的最新进展。

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来源期刊

Dyes and Pigments 工程技术-材料科学：纺织

CiteScore

8.20

自引率

13.30%

发文量

933

审稿时长

33 days

期刊介绍： Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied. Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media. The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.

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