Transportation engineering for enhanced production of plant natural products in microbial cell factories

IF 4.4 2区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Synthetic and Systems Biotechnology Pub Date : 2024-06-03 DOI:10.1016/j.synbio.2024.05.014

Yimeng Zuo , Minghui Zhao , Yuanwei Gou , Lei Huang , Zhinan Xu , Jiazhang Lian

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引用次数: 0

Abstract

Plant natural products (PNPs) exhibit a wide range of biological activities and have essential applications in various fields such as medicine, agriculture, and flavors. Given their natural limitations, the production of high-value PNPs using microbial cell factories has become an effective alternative in recent years. However, host metabolic burden caused by its massive accumulation has become one of the main challenges for efficient PNP production. Therefore, it is necessary to strengthen the transmembrane transport process of PNPs. This review introduces the discovery and mining of PNP transporters to directly mediate PNP transmembrane transportation both intracellularly and extracellularly. In addition to transporter engineering, this review also summarizes several auxiliary strategies (such as small molecules, environmental changes, and vesicles assisted transport) for strengthening PNP transportation. Finally, this review is concluded with the applications and future perspectives of transportation engineering in the construction and optimization of PNP microbial cell factories.

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在微生物细胞工厂加强植物天然产品生产的运输工程

植物天然产物（PNPs）具有广泛的生物活性，在医药、农业和香料等多个领域都有重要应用。鉴于其天然局限性，近年来利用微生物细胞工厂生产高价值的 PNPs 已成为一种有效的替代方法。然而，大量积累造成的宿主代谢负担已成为高效生产 PNP 的主要挑战之一。因此，有必要加强 PNPs 的跨膜转运过程。本综述介绍了 PNP 转运体的发现和挖掘，以直接介导 PNP 在细胞内和细胞外的跨膜转运。除了转运体工程学，本综述还总结了几种加强 PNP 转运的辅助策略（如小分子、环境变化和囊泡辅助转运）。最后，本综述总结了运输工程在构建和优化 PNP 微生物细胞工厂中的应用和未来展望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Synthetic and Systems Biotechnology BIOTECHNOLOGY & APPLIED MICROBIOLOGY-

CiteScore

6.90

自引率

12.50%

发文量

审稿时长

67 days

期刊介绍： Synthetic and Systems Biotechnology aims to promote the communication of original research in synthetic and systems biology, with strong emphasis on applications towards biotechnology. This journal is a quarterly peer-reviewed journal led by Editor-in-Chief Lixin Zhang. The journal publishes high-quality research; focusing on integrative approaches to enable the understanding and design of biological systems, and research to develop the application of systems and synthetic biology to natural systems. This journal will publish Articles, Short notes, Methods, Mini Reviews, Commentary and Conference reviews.