EXAMINING CARICA PAPAYA LEAF EXTRACT'S POTENTIAL FOR TREATING RATS' HEPATOTOXICITY AND NEPHROTOXICITY CAUSED BY PARACETAMOL.

Abstract

Carica papaya is an important economic plant that has many nutritional advantages and, remarkable medicinal purposes including treatment of a wide range of illnesses. Thus, the purpose of this study was to determine how well carica papaya leaf extract mitigates the effects of paracetamol on blood biochemical markers and oxidative damage of rats. Six groups each group consists of six male albino rats, weighing 150 ± 15 g, were created. Group one consisted of a healthy group; Group two consisted of rats given an ethanol papaya extract (100 mg/kg body weight); Group three consisted of rats given an ethanol papaya extract (200 mg/kg body weight).Rats in group four were given paracetamol (2g/kg b.wt). Rats in group five received a pretreatment of carica papaya extract (100 mg/kg body weight) and a 30-minute paracetamol treatment. Rats in group six received 200 mg/kg body weight of carica papaya extract as a pretreatment before receiving paracetamol. The experiment continued for two months. The group receiving paracetamol showed a significant increase in blood markers, including urea, creatinine, AST, ALT, and ALP. As a result of these findings, preventing oxidative stress caused by paracetamol was achieved through pretreatment with carica papaya extract which improved antioxidant enzymes (CAT and SOD). According to these results, paracetamol-induced liver and kidney damage can be prevented by the hepato-protective and nephroprotective actions of Carica papaya leaf extract. lowering oxidative stress, boosting antioxidant defenses, encouraging liver cell regeneration, and regaining normal liver and kidney function, helps in mitigating liver and kidney damage.