Epidemiology of malaria in Gabon: A systematic review and meta-analysis from 1980 to 2023

IF 4.7 3区医学 Q1 INFECTIOUS DISEASES

Journal of Infection and Public Health Pub Date : 2024-06-03 DOI:10.1016/j.jiph.2024.05.047

Yann Vital Sima-Biyang , Steede Seinnat Ontoua , Neil Michel Longo-Pendy , Clark Mbou-Boutambe , Patrice Makouloutou-Nzassi , Cyr Kinga Moussadji , Jean-Bernard Lekana-Douki , Larson Boundenga

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引用次数: 0

Abstract

The objective of this were conducted to elucidate spatiotemporal variations in malaria epidemiology in Gabon since 1980. For that, five databases, were used to collect and identify all studies published between 1980 and 2023 on malaria prevalence, antimalarial drug resistance, markers of antimalarial drug resistance and insecticide resistance marker. The findings suggest that Gabon continues to face malaria as an urgent public health problem, with persistently high prevalence rates. Markers of resistance to CQ persist despite its withdrawal, and markers of resistance to SP have emerged with a high frequency, reaching 100 %, while ACTs remain effective. Also, recent studies have identified markers of resistance to the insecticides Kdr-w and Kdr-e at frequencies ranging from 25 % to 100 %. Ace1R mutation was reported with a frequency of 0.4 %. In conclusion, the efficacy of ACTs remains above the threshold recommended by the WHO. Organo-phosphates and carbamates could provide an alternative for vector control.

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加蓬的疟疾流行病学：1980 年至 2023 年的系统回顾和元分析

本研究旨在阐明自 1980 年以来加蓬疟疾流行病学的时空变化。为此，研究人员利用五个数据库收集并确定了 1980 年至 2023 年间发表的所有关于疟疾流行率、抗疟药物抗药性、抗疟药物抗药性标记和杀虫剂抗药性标记的研究。研究结果表明，加蓬仍然面临着疟疾这一紧迫的公共卫生问题，疟疾流行率居高不下。尽管 CQ 已经停用，但其抗药性标记仍然存在；尽管 ACTs 仍然有效，但 SP 的抗药性标记出现频率很高，达到 100%。最近的研究还发现了对杀虫剂 Kdr-w 和 Kdr-e 的抗药性标记，频率从 25% 到 100% 不等。据报道，Ace1R 突变的频率为 0.4%。总之，青蒿素综合疗法的疗效仍高于世卫组织建议的临界值。有机磷酸盐和氨基甲酸酯类药物可作为病媒控制的替代品。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Infection and Public Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH -INFECTIOUS DISEASES

CiteScore

13.10

自引率

1.50%

发文量

203

审稿时长

96 days

期刊介绍： The Journal of Infection and Public Health, first official journal of the Saudi Arabian Ministry of National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences and the Saudi Association for Public Health, aims to be the foremost scientific, peer-reviewed journal encompassing infection prevention and control, microbiology, infectious diseases, public health and the application of healthcare epidemiology to the evaluation of health outcomes. The point of view of the journal is that infection and public health are closely intertwined and that advances in one area will have positive consequences on the other. The journal will be useful to all health professionals who are partners in the management of patients with communicable diseases, keeping them up to date. The journal is proud to have an international and diverse editorial board that will assist and facilitate the publication of articles that reflect a global view on infection control and public health, as well as emphasizing our focus on supporting the needs of public health practitioners. It is our aim to improve healthcare by reducing risk of infection and related adverse outcomes by critical review, selection, and dissemination of new and relevant information in the field of infection control, public health and infectious diseases in all healthcare settings and the community.