Pseudoternary Phase Diagram and Antibacterial Activity of Microemulsion-Based Citronella Oil

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-06-01 DOI:10.22146/ijc.93250

C. Gunarto, A. Go, Artik Elisa Angkawijaya, Jenni Lie, F. Soetaredjo, S. Ismadji, N. Puspitasari, J. N. Putro, Chandra Risdian

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Abstract

Citronella oil (CTO) is extracted from citronella leaves by maceration or steam distillation process, which has antibacterial and insect-repellent activities. However, the use of CTO is limited and requires modification in other formulations, such as microemulsion (ME), to increase its bioactivities. ME consists of oil, water, surfactant and/or cosurfactant and is commonly applied in food and beverages, cosmetics, and carrier for drug delivery applications. CTO was used as the oil phase for ME with nonionic surfactant and ethanol as a cosurfactant for lowering interfacial tension between oil and water phase. Subsequent observations regarding stability and antibacterial tests were carried out on ME formulations with surfactant/cosurfactant mixture of 2 due to its largest ME area. A hydrodynamic diameter analysis was also carried out to see the stability of the ME within a period of 50 d. ME with 10% CTO, 30% surfactant mixture, and 60% water showed the best formulation observed from the consistent hydrodynamic diameter measurement. In addition, ME with different formulations could inhibit the growth of Escherichia coli and Staphylococcus aureus by more than 90%. From this research, CTO-based ME potentially improve and develop drug carrier applications, especially via topical route.

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微乳液型香茅油的假三元相图和抗菌活性

香茅油（CTO）是通过浸渍或蒸汽蒸馏工艺从香茅叶中提取的，具有抗菌和驱虫活性。不过，CTO 的使用范围有限，需要在微乳剂（ME）等其他配方中加以改良，以提高其生物活性。微乳剂由油、水、表面活性剂和/或助表面活性剂组成，通常用于食品和饮料、化妆品以及给药载体。CTO 用作 ME 的油相，非离子表面活性剂和乙醇作为辅助表面活性剂，可降低油相和水相之间的界面张力。由于 2 号表面活性剂/共表面活性剂混合物的 ME 面积最大，因此对其进行了稳定性观察和抗菌测试。此外，还进行了流体力学直径分析，以了解 ME 在 50 天内的稳定性。从一致的流体力学直径测量结果来看，含 10%CTO、30%表面活性剂混合物和 60%水的 ME 是最佳配方。此外，不同配方的 ME 对大肠杆菌和金黄色葡萄球菌的生长抑制率超过 90%。通过这项研究，基于 CTO 的 ME 有可能改善和开发药物载体的应用，特别是通过局部途径。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.